Dental Composition with High-Potency Sweetener
The present invention relates generally to dental compositions comprising non-caloric or low-caloric high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different dental compositions comprising at least one non-caloric or low-caloric natural and/or synthetic high-potency sweetener, at least one sweet taste improving composition, and an active dental substance. The present invention also relates to dental compositions and methods that can improve the tastes of non-caloric or low-caloric natural and/or synthetic, high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the dental compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like flavor profile.
1 . A dental composition comprising:
an active dental substance;
at least one high-potency sweetener; and
at least one sweet taste improving composition.
2 . The dental composition of claim 1 , wherein the at least one high-potency sweetener comprises a natural high-potency sweetener selected from the group consisting of rebaudioside A, rebaudioside B, rebaudioside C, rebaudioside D, rebaudioside E, rebaudioside F, dulcoside A, dulcoside B, rubusoside, stevia, stevioside, mogroside IV, mogroside V, Luo Han Guo sweetener, siamenoside, monatin and its salts (monatin SS, RR, RS, SR), curculin, glycyrrhizic acid and its salts, thaumatin, monellin, mabinlin, brazzein, hemandulcin, phyllodulcin, glycyphyllin, phloridzin, trilobatin, baiyanoside, osladin, polypodoside A, pterocaryoside A, pterocaryoside B, mukurozioside, phlomisoside I, periandrin I, abrusoside A, cyclocarioside I, and combinations thereof.
3 . The dental composition of claim 1 , wherein the at least one high-potency sweetener comprises a synthetic high-potency sweetener selected from the group consisting of sucralose, acesulfame potassium and other salts, aspartame, alitame, saccharin, neohesperidin dihydrochalcone, cyclamate, neotame, N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester, N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester, N-[N-[3-(3-methoxy-4-hydroxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester, salts thereof, and combinations thereof.
4 . The dental composition of claim 1 , wherein the at least one sweet taste improving composition comprises a first sweet taste improving composition selected from the group consisting of carbohydrates, polyols, amino acids and their corresponding salts, polyamino acids and their corresponding salts, sugar acids and their corresponding salts, organic acids, inorganic acids, organic salts, inorganic salts, bitter compounds, flavorants, astringent compounds, polymers, proteins or protein hydrolysates, surfactants, emulsifiers, flavonoids, alcohols, and combinations thereof.
5 . The dental composition of claim 1 , wherein the at least one sweet taste improving composition imparts a more sugar-like temporal profile to the dental composition than the sweetener would have without the at least one sweet taste improving composition.
6 . The dental composition of claim 1 , further comprising at least one second sweet taste improving composition different from the at least one first sweet taste improving composition and selected from the group consisting of carbohydrates, polyols, amino acids and their corresponding salts, polyamino acids and their corresponding salts, sugar acids and their corresponding salts, organic acids, inorganic acids, organic salts, inorganic salts, bitter compounds, flavorants, astringent compounds, polymers, proteins or protein hydrolysates, surfactants, emulsifiers, flavonoids, alcohols, and combinations thereof.
7 . The dental composition of claim 6 , further comprising at least one third sweet taste improving composition different from the at least one first sweet taste improving composition and the at least one second sweet taste improving composition and selected from the group consisting of carbohydrates, polyols, amino acids and their corresponding salts, polyamino acids and their corresponding salts, sugar acids and their corresponding salts, organic acids, inorganic acids, organic salts, inorganic salts, bitter compounds, flavorants, astringent compounds, polymers, proteins or protein hydrolysates, surfactants, emulsifiers, flavonoids, alcohols, and combinations thereof.
8 . The dental composition of claim 1 , wherein the at least one high-potency sweetener is rebaudioside A, stevioside, stevia, or combinations thereof.
9 . The dental composition of claim 8 , wherein the at least one sweet taste improving composition comprises a polyol.
10 . The dental composition of claim 9 , wherein the at least one polyol comprises erythritol.
11 . The dental composition of claim 9 , wherein the at least one polyol comprises xylitol.
12 . The dental composition of claim 8 , wherein the at least one sweet taste improving composition comprises at least one amino acid.
13 . The dental composition of claim 12 , wherein the at least one amino acid comprises glycine, alanine, proline, hydroxyproline, glutamine, or combinations thereof.
14 . The dental composition of claim 8 , wherein the at least one sweet taste improving composition comprises at least one polyamino acid.
15 . The dental composition of claim 14 , wherein the at least one polyamino acid comprises poly-L-aspartic acid, poly-L-α-lysine, poly-L-ε-lysine, poly-L-α-omithine, poly-ε-ornithine, poly-L-arginine, salts thereof, or combinations thereof.
16 . The dental composition of claim 8 , wherein the at least one sweet taste improving composition comprises at least one inorganic salt.
17 . The dental composition of claim 16 , wherein the at least one inorganic salt comprises a sodium, potassium, calcium, or magnesium salt.
18 . The dental composition of claim 16 , further comprising at least one inorganic phosphate.
19 . The dental composition of claim 18 , wherein the at least one inorganic phosphate comprises a sodium, potassium, calcium, or magnesium phosphate.
20 . The dental composition of claim 16 , further comprising at least one inorganic chloride.
21 . The dental composition of claim 20 , wherein the at least one inorganic chloride comprises a sodium, potassium, calcium, or magnesium chloride.
22 . The dental composition of claim 8 , wherein the at least one sweet taste improving composition comprises at least one carbohydrate.
23 . The dental composition of claim 22 , wherein the at least one carbohydrate comprises sucrose, high fructose corn syrup, glucose, or sucrose.
24 . The dental composition of claim 23 , wherein the at least one carbohydrate is present in the dental composition in an amount from about 10,000 ppm to about 80,000 ppm of the composition.
25 . The dental composition of claim 8 , wherein the at least one sweet taste improving composition comprises at least one synthetic high-potency sweetener.
26 . The dental composition of claim 25 , wherein the at least one synthetic high-potency sweetener comprises sucralose, acesulfame potassium or other salts, aspartame, alitame, saccharin, neohesperidin dihydrochalcone, cyclamate, neotame, N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester, N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester, N- [-[3-(3-methoxy-4-hydroxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester, salts thereof, and combinations thereof.
27 . The dental composition of claim 25 , wherein the at least one synthetic high-potency sweetener comprises saccharin or acesulfame potassium or other salts.
28 . The dental composition of claim 27 , wherein the at least one synthetic sweetener is present in the dental composition in an amount from about 10 ppm to about 100 ppm of the composition.
29 . The dental composition of claim 8 , wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 70% rebaudioside A by weight on a dry basis.
30 . The dental composition of claim 8 , wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 80% rebaudioside A by weight on a dry basis.
31 . The dental composition of claim 8 , wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 90% rebaudioside A by weight on a dry basis.
32 . The dental composition of claim 8 , wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 97% rebaudioside by weight on a dry basis.
33 . The dental composition of claim 8 , wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 98% rebaudioside by weight on a dry basis.
34 . The dental composition of claim 8 , wherein the rebaudioside A comprises rebaudioside A in a purity greater than about 99% rebaudioside by weight on a dry basis.
35 . The dental composition of claim 1 , wherein the dental composition is selected from the group consisting of mouth freshening agents, gargling agents, mouth rinsing agents, toothpaste, tooth polish, dentifrices, mouth sprays, teeth-whitening agent, dental floss, and combinations thereof.
36 . The dental composition of claim 1 , wherein the active dental substance comprises a substance selected from the group consisting of anticaries drugs, fluoride, sodium fluoride, sodium monofluorophosphate, stannos fluoride, hydrogen peroxide, carbamide peroxide, antibacterial agents, plaque removing agents, stain removers, anticalculus agents, abrasives, baking soda, percarbonates, perborates of alkali and alkaline earth metals, and combinations thereof.
37 . The dental composition of claim 1 , further comprising a bulk sweetener.
38 . The dental composition of claim 1 , wherein the sweet taste improving composition functions as a bulk sweetener.
39 . The dental composition of claim 1 , wherein the active dental substance is present in the dental composition in an amount in the range of about 50 ppm to about 3000 ppm of the dental composition.
40 . The dental composition of claim 1 , wherein the natural high-potency sweetener is present in the dental composition in an amount in th range of about 1 ppm to about 5,000 ppm of the dental composition.
41 . The dental composition of claim 1 , wherein the sweet taste improving composition is present in the dental composition in an amount in the range of about 0.1 ppm to about 100,000 of the dental composition.