Electrospray apparatus with an integrated electrode
View Patent ↗The invention provides related apparatus and methods of making an integrated electrospray tip by depositing ionic and/or electronic conductor materials onto a planar substrate. The invention also features methods of forming an electrospray apparatus comprising coupling a first planar substrate to the surface of a second planar substrate, wherein a surface on at least one of the substrates includes one or more microfluidic channels and/or reservoirs which are at least partially or totally enclosed therebetween. The conductive regions of the apparatus do not intersect the microfluidic channels within other portions of the apparatus provided preferably. The invention further provides related apparatus and methods for manufacturing and using microfluidic devices with integrated electrodes for electrospray ionization. The electrospray apparatus in some embodiments may include an electronic conductor electrode or an ionic conductor electrode formed from a microfluidic channel containing a conductive material selected from a variety of solutions and gels.
1. An electrospray apparatus comprising:
a first planar substrate coupled to a second planar substrate to form at least one microfluidic channel that is at least partially enclosed, and
wherein said first planar substrate includes a conductive region that does not intersect the microfluidic channel; and at least one of said first and second planar substrates tapers to form an edge-emitting electrospray tip.
2. The electrospray apparatus as recited in claim 1 wherein at least one of said first and second planar substrates contains another microfluidic channel and/or reservoir.
3. An electrospray apparatus comprising:
a first planar substrate coupled to a second planar substrate to form at least one microfluidic channel that is at least partially enclosed therebetween, and
wherein said first planar substrate having a conductive region that includes a selected ionic conductor serving as an electrode which does not directly contact the microfluidic channel; and at least one of said first and second planar substrates tapers to form an edge-emitting electrospray tip.
4. The electrospray apparatus as recited in claim 3 wherein at least one of said first and second planar substrates contains another microfluidic channel and/or reservoir.
5. An electrospray apparatus comprising:
a first planar substrate coupled to a second planar substrate which forms at least a partially enclosed microfluidic channel, and
wherein said first planar substrate contains an ionic conductor electrode that does not intersect any portion of the microfluidic channel; and at least one of said first and second planar substrates tapers to form an edge-emitting electrospray tip.
6. The electrospray apparatus as recited in claim 5 wherein at least one of said first and second planar substrates contains another microfluidic channel and/or reservoir.