DETACHABLE THERAPEUTIC MATERIAL
The invention provides implantable devices comprising a biocompatible material that provides a structural function or therapeutic function or both. The devices are configured to be detachable or releasable from a distal portion of a delivery instrument such as a catheter.
1 . An implantable device comprising a biocompatible material releasably attachable to a delivery instrument for placement within in the body, wherein the material comprises perforations therein.
2 . The device of claim 1 , wherein the material comprises perforations at a proximal end of the device configured for releasable attachment to the delivery instrument.
3 . The device of claim 1 , wherein the material comprises perforations at a distal end of the device configured for releasable attachment to the delivery instrument.
4 . The device of claim 1 , wherein the material comprises perforations at a proximal end and a distal end of the device configured for releasable attachment to the delivery instrument.
5 . The device of claim 1 , wherein the device is releasable from the delivery instrument by breaking the perforations.
6 . The device of claim 1 , wherein the device has a tubular, hollow or planar configuration.
7 . The device of claim 1 , wherein the device is self-expandable upon release from the delivery instrument.
8 . The device of claim 1 , wherein the device is expandable upon application of a radial force on an interior surface of the device.
9 . The device of claim 1 , wherein the perforations are circumferentially placed about the device when releasably attached to the delivery device.
10 . The device of claim 1 , wherein the perforations are in linear alignment with the longitudinal axis of the delivery instrument.
11 . The device of claim 1 , wherein the material is biodegradable or bioresorbable.
12 . The device of claim 1 , wherein the material further comprises a therapeutic agent which is eludable from the material.
13 . The device of claim 1 , wherein the material comprises an extracellular matrix.
14 . A system for treating a defect at a target tissue site within the body, the system comprising:
a catheter; and
an implantable material releasably attached at a distal portion of the catheter, wherein the material comprises perforations therein.
15 . The system of claim 14 , wherein the implantable material has a tubular configuration when releasably attached to the catheter.
16 . The system of claim 15 , further comprising a mechanism positioned within the tubular material for exerting a radial force on the tubular material sufficient to separate the perforations.
17 . The system of claim 16 , wherein the perforations are positioned circumferentially about the tubular material.
18 . The system of claim 16 , wherein the perforations are positioned longitudinally along the tubular material.
19 . The system of claim 16 , wherein the mechanism is an inflatable balloon or an expandable mesh.
20 . The system of claim 15 , wherein the material retains a tubular configuration when released from the catheter.
21 . The system of claim 15 , wherein the material has a planar configuration when released from the catheter.
22 . A method of making a device for delivery to a body lumen, the device comprising a material which is configured to induce a biological or therapeutic effect when placed at tissue site within the body, the method comprising:
forming the material in the desired shape and having the desired dimensions;
applying perforations in the material, and
attaching the material to a catheter for delivery to within the body, wherein the perforations are arranged relative to the catheter such that breaking the perforations releases the device from the catheter.
23 . The method of claim 22 , wherein forming the material comprises a process selected from the group consisting of extruding, sewing, laminating, pressing, freeze-drying, gluing, and molding.
24 . The method of claim 22 , wherein the material is selected from the group consisting of extracellular matrix derived from a mammal, synthetic extracellular matrix, an extruded material, a biodegradable material, and a drug eluting material.
25 . A method of treating a tissue site within the body, comprising:
releasing a device in the vessel lumen of a living body from a distal portion of a catheter by breaking perforations provided in the device, wherein the device comprises a material for inducing a biological or therapeutic effect at the tissue site.
26 . The method of claim 25 , wherein the material contains at least one therapeutic agent and the method further comprises eluding the at least one therapeutic agent from the material.
27 . The method of claim 26 , wherein the material comprises multiple layers, each containing at least one therapeutic agent, wherein the method further comprises eluding the therapeutic agents sequentially.
28 . The method of claim 25 , further comprising buttressing the vessel lumen with the released device.