IP Library Granted Patent US 8,273,794
Granted Patent B2
US 8,273,794 · App. 11/569,004 · Granted Sep 25, 2012

Compounds and compositions for delivering active agents

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Quick Facts
Patent No.
US 8,273,794
App. No.
11/569,004
Granted
Sep 25, 2012
Kind
B2
Abstract

Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

Claims (49)

1. A compound selected from:

and salts thereof.

2. A pharmaceutical composition comprising:

(A) at least one biologically active agent; and

(B) a compound of claim 1 .

3. The pharmaceutical composition of claim 2 , wherein said biologically active agent is selected from the group consisting of

Amylin, Amylin Agonists, Adrenocorticotropin, Antigens, Antimicrobials, Antibiotics, Anti-Bacteria's, Anti-Fungal Agents, Anti-Migraine Agents, Calcitonin Gene-Related Protein Antagonists, Sumatriptan Succinate, Antivirals, Atrial Naturetic Factor, Bisphosphonates, Salmon Calcitonin, Eel Calcitonin, Porcine Calcitonin, Human Calcitonin, Cholecystokinin (CCK), CCK Agonists; Cromolyn Sodium, Cyclosporine, Desferrioxamine (DFO), Erythropoietin, Exedin, Exedin Agonists, Filgrastim, Follicle Stimulating Hormone, Glucagon-Like Peptide 1 (GLP-1), Glucagon, Glucagon-Like Peptide 2 (GLP-2); Glucocerebrosidase, Gonadotropin Releasing Hormone, Growth Hormone Releasing Factor; Growth Hormone Releasing Hormones, Growth Hormones, Human Growth Hormones (hGH), Recombinant Human Growth Hormones (rhGH), Bovine Growth Hormones, Porcine Growth Hormones; Heparin, Unfractionated Heparin, Heparinoids, Dermatans, Chondroitins, Low Molecular Weight Heparin, Very Low Molecular Weight Heparin, Ultra Low Molecular Weight Heparin, synthetic heparins, Porcine Insulin, Bovine Insulin, Human Insulin, Human Recombinant Insulin; Insulin-Like Growth Factor, IGF-1; Interferons, α Interferons, β Interferons, θ Interferons, γ Interferons; Interleukin-1; Interleukin-2; Interleukin-11; Interleukin-21; Leutinizing Hormone, Leutinizing Hormone Releasing Hormone, Leptin, Monoclonal Antibodies, TNF-alpha soluble receptors, Oxytocin, Parathyroid Hormone (PTH), PTH fragments, PTH 1-34, PTH 1-38, Peptide YY (PYY), PYY Agonists, Prostaglandins; Protease Inhibitors, Somatostatin, Thrombopoietin, Vancomycin, Vasopressin, Vitamins, Vaccines, and combinations thereof.

4. A compound selected from:

and salts thereof.

5. A pharmaceutical composition comprising:

(A) at least one biologically active agent; and

(B) a compound of claim 4 .

6. A pharmaceutical composition comprising:

(A) at least one biologically active agent; and

(B) a compound selected from:

and salts thereof, wherein

said biologically active agent is selected from the group consisting of Amylin, Amylin Agonists, Adrenocorticotropin, Antigens, Antimicrobials, Antibiotics, Anti-Bacterials, Anti-Fungal Agents, Anti-Migraine Agents, Calcitonin Gene-Related Protein Antagonists, Sumatriptan Succinate, Antivirals, Atrial Naturetic Factor, Bisphosphonates, Salmon Calcitonin, Eel Calcitonin, Porcine Calcitonin, Human Calcitonin, Cholecystokinin (CCK), CCK Agonists; Cromolyn Sodium, Cyclosporine, Desferrioxamine (DFO), Erythropoietin, Exedin, Exedin Agonists, Filgrastim, Follicle Stimulating Hormone, Glucagon-Like Peptide 1 (GLP-1), Glucagon, Glucagon-Like Peptide 2 (GLP-2); Glucocerebrosidase, Gonadotropin Releasing Hormone, Growth Hormone Releasing Factor; Growth Hormone Releasing Hormones, Growth Hormones, Human Growth Hormones (hGH), Recombinant Human Growth Hormones (rhGH), Bovine Growth Hormones, Porcine Growth Hormones; Heparin, Unfractionated Heparin, Heparinoids, Dermatans, Chondroitins, Low Molecular Weight Heparin, Very Low Molecular Weight Heparin, Ultra Low Molecular Weight Heparin, synthetic heparins, Porcine Insulin, Bovine Insulin, Human Insulin, Human Recombinant Insulin; Insulin-Like Growth Factor, IGF-1; Interferons, α Interferons, β Interferons, θ Interferons, γ Interferons; Interleukin-1; Interleukin-2; Interleukin-11; Interleukin-21; Leutinizing Hormone, Leutinizing Hormone Releasing Hormone, Leptin, Monoclonal Antibodies, TNF-alpha soluble receptors, Oxytocin, Parathyroid Hormone (PTH), PTH fragments, PTH 1-34, PTH 1-38, Peptide YY (PYY), PYY Agonists, Prostaglandins; Protease Inhibitors, Somatostatin, Thrombopoietin, Vancomycin, Vasopressin, Vitamins, Vaccines, and combinations thereof.

7. A compound selected from:

and salts thereof.

8. A pharmaceutical composition comprising:

(A) at least one biologically active agent; and

(B) a compound of claim 7 .

9. A pharmaceutical composition comprising:

(A) at least one biologically active agent; and

(B) a compound selected from

and salts thereof.

10. A compound selected from:

and salts thereof.

11. A pharmaceutical composition comprising:

(A) at least one biologically active agent; and

(B) a compound of claim 10 .

12. A compound selected from:

and salts thereof.

13. A pharmaceutical composition comprising:

(A) at least one biologically active agent; and

(B) a compound of claim 12 .

14. The pharmaceutical composition of claim 2 , wherein the biologically active agent is recombinant human growth hormone.

15. The pharmaceutical composition of claim 2 , wherein the biologically active agent is insulin.

16. The pharmaceutical composition of claim 2 , wherein the biologically active agent is heparin.

17. The pharmaceutical composition of claim 2 , wherein the biologically active agent is calcitonin.

18. The pharmaceutical composition of claim 2 , wherein the biologically active agent is interferon.

19. The pharmaceutical composition of claim 2 , wherein the biologically active agent is cromolyn sodium.

20. A compound according to claim 1 , selected from Compounds 3, 4, 6, 8, 11, 13, 14, 16, 18, 19, 20, 21, and salts thereof.

21. A pharmaceutical composition comprising (A) at least one biologically active agent and (B) a compound of claim 20 .

22. A compound according to claim 4 , selected from Compounds 23-27, 30-35, 38, 39, 41-49, 51-55, 57-59, 61-65, 68, 69, 71-78, 80-85, 87, 88, 90-96, 98-104, 106-108, 110, and salts thereof.

23. A pharmaceutical composition comprising (A) at least one biologically active agent and (B) a compound of claim 22 .

24. A compound selected from

and salts thereof.

25. A pharmaceutical composition comprising (A) at least one biologically active agent and (B) a compound of claim 24 .

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 29, 2022
From: NOVO NORDISK NORTH AMERICA OPERATIONS A/S
To: NOVO NORDISK A/S
Reel/Frame 060352/0663 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 22, 2021
From: EMISPHERE TECHNOLOGIES, INC.
To: NOVO NORDISK NORTH AMERICA OPERATIONS A/S
Reel/Frame 056750/0169 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 8, 2007
From: GOMEZ-ORELLANA, MARIA ISABEL; GSCHNEIDNER, DAVID; LEONE-BAY, ANDREA; MOYE-SHERMAN, DESTARDI; PUSZTAY, STEPHEN V.; RATH, PARSHURAM; TANG, PINGWAH; WEIDNER, JOHN J.; SONG, JIANFENG
To: EMISPHERE TECHNOLOGIES, INC.
Reel/Frame 018723/0654 →