Use of gingival fibroblasts for vascular cell therapy
View Patent ↗The invention relates to the use of gingival fibroblasts for obtaining a cellular composition for treating arterial-remodelling pathology, for example an aneurysm, post-cryoplasty stenosis and restenosis, an aortic dissection or atherosclerosis.
1. A method for treating an arterial-remodeling pathology, said pathology being selected from the group consisting of an aneurism and a post-angioplasty stenosis or restenosis, comprising obtaining fibroblasts from gingival tissue taken from an individual, culturing said gingival fibroblasts, and implanting said cultured gingival fibroblasts into the wall of a lesioned artery of said individual.
2. A method for treating an arterial-remodeling pathology in an individual suffering from an arterial-remodeling pathology involving an excessive activity of MMP9, said pathology being selected from the group consisting of an aneurism and post-angioplasty stenosis or restenosis, comprising obtaining fibroblasts from gingival tissue take from an individual, culturing said gingival fibroblasts, and implanting said cultured gingival fibroblasts into the wall of a lesioned artery of said individual.
3. A method for treating an arterial-remodeling pathology, wherein said method comprises implanting gingival fibroblasts into the wall of a lesioned artery, and wherein said pathology is an aneurism.
4. The method of claim 3 , wherein said fibroblasts are derived from gingival tissue taken beforehand from the individual for whom the treatment is intended.
5. A method for treating an arterial-remodeling pathology, wherein said method comprises implanting gingival fibroblasts into the wall of a lesioned artery, and wherein said pathology is a post-angioplasty stenosis or restenosis.
6. The method of claim 5 , wherein said fibroblasts are derived from gingival tissue taken beforehand from the individual for whom the treatment is intended.