Diagnostic and/or Remedy for Ovarian Cancer
It was found that an antibody containing the amino acid sequences described in the sequence listing as SEQ ID NOS: 1 to 6 was an antibody having reactivity also to ovarian cancer, as well as the cancer species known so far such as gastric cancer, colon cancer and breast cancer, and was useful as an ovarian cancer tissue-specific diagnostic and/or therapeutic agent.
1 - 14 . (canceled)
15 : A diagnostic and/or therapeutic agent for ovarian cancer, which com rises an antibody containing the amino acid sequence of any one of SEQ ID NOS: 1 to 6 described in the sequence listing.
16 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 15 , wherein the ant-body contains the amino acid sequences of SEQ ID NOS: 1, 2 and 3 described in the sequence listing in a hypervariable region of a heavy chain, and the amino acid sequences of SEQ ID NOS: 4, 5 and 6 described in the sequence listing in a hypervariable region of a light chain.
17 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 15 , wherein he antibody contains the amino acid sequence of SEQ ID NO: 7 described in the sequence listing in a heavy chain variable region, a amino acid sequence of SEQ ID NO: 8 described in the sequence listing in a light chain variable region.
18 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 16 , wherein the antibody contains the amino acid sequence of SEQ ID NO: 7 described in the sequence listing in a heavy chain variable region, and the amino acid sequence of SEQ ID NO: 8 described in the sequence listing in a light chair variable region.
19 : A diagnostic and/or therapeutic agent for ovarian cancer, which comprises the antibody according to claim 15 and a liposome encapsulating a medicament.
20 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 19 , wherein the antibody binds to the liposome by means of a thioether group.
21 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 19 , wherein the antibody binds to the liposome in which a part of lipid ends is maleimidated by means of a thioether group.
22 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 20 , wherein the antibody binds to the liposome in which a part of lipid ends is maleimidated by means of a thioether group.
23 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 21 , wherein the antibody binds in an amount of 0.1 to 2 mole % based on a molar amount of the maleimidated lipid.
24 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 22 , wherein the antibody binds in an amount of 0.1 to 2 mole % based on a molar amount of the maleimodated lipid.
25 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 19 , wherein the antibody is an F(ab′) 2 fragment.
26 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 19 , wherein the liposome binds a compound containing a polyalkylene glycol moiety.
27 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 26 , wherein the compound containing a polyalkylene glycol moiety binds in an amount of 15 to 50 mole % based on a molar amount of the maleimidated lipid contained in the liposome.
28 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 26 , wherein the compound containing a polyalkylene glycol moiety is a compound having two polyalkylene glycol moieties.
29 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 27 , wherein the compound containing a polyalkylene glycol moiety is a compound having two polyalkylene glycol moieties.
30 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 26 , wherein the polyalkylene glycol moiety is derived from a polyethylene glycol.
31 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 30 , wherein the polyethylene has a molecular weight of 2000 to 7000 daltons.
32 : The diagnostic and/or therapeutic agent for ovarian cancer according to claim 19 , wherein the medicament is an antitumor substance.