Method for the Production of a Wound Pad
The invention relates to a method for producing a wound pad, by means of which the permeability of the wound pad can be adjusted. The inventive method makes it possible to produce wound pads for a wide range of therapeutic applications.
1 . A method for producing a wound dressing having a permeable polymer matrix, wherein the permeability of the wound dressing is preselected and a plasticizer is used, depending on the selected permeability of the wound dressing, wherein the plasticizer is dissolved and the concentration of the plasticizer in the solution is adjusted according to a correlation between the plasticizer concentration and the permeability ascertained for the particular polymer matrix and the particular plasticizer.
2 . The method according to claim 1 , wherein the plasticizer is added to a solution of a polymer and the polymer solution mixed with the plasticizer is then processed further to produce the wound dressing.
3 . The method according to claim 1 , wherein a polymer membrane is produced and this polymer membrane is then transferred to the solution with the plasticizer.
4 . The method according to claim 1 , wherein the polymer is chitosan with a weight-average molecular weight of at least 100,000 g/mol.
5 . The method according to claim 4 , wherein instead of the chitosan, a chitosan salt obtainable by dehydrating an acidic solution of chitosan is used.
6 . The method according to claim 1 , wherein the plasticizer is glycerol, a citric acid ester, glycerol triacetate, 1,2-propanediol, 1,2-propylene glycol or polyethylene glycol with a low molecular weight of up to 400 g/mol.
7 . The method according to claim 1 , wherein the water vapor permeability of the wound dressing is increased with an increase in the concentration of the plasticizer.
8 . The method according to claim 2 , wherein the concentration of the plasticizer in the polymer solution is 0.01 to 3.0 percent by weight.
9 . The method according to claim 8 , wherein the polymer solution mixed with the plasticizer is processed further to form a polymer membrane in the form of a film.
10 . The method according to claim 1 , wherein the pore structure of the polymer matrix is adjusted.
11 . The method according to claim 10 , wherein particles are added to the polymer solution and then these particles are dissolved out of the polymer membrane after further processing the polymer solution to yield a polymer membrane.
12 . The method according to claim 11 , wherein the particles are silicate particles.
13 . The method according to claim 10 , wherein polyethylene glycol is added to the polymer solution and the polyethylene glycol is dissolved out of the polymer membrane after further processing of the polymer solution to form a polymer membrane.
14 . The method according to claim 13 , wherein polyethylene glycol with a molecular weight of 1500 to 100,000 g/mol is used.