Therapy for treatment of chronic degenerative brain diseases and nervous system injury
View Patent ↗In one aspect the present invention provides neuroactive steroids for use in the treatment of nervous system disorders, degenerative brain diseases and congenital storage diseases. In a second aspect the invention provides neuroactive steroids in combination with a Liver X Receptor (LXR) ligand to effect treatment of a nervous system condition.
1. A method of treating Niemann-Pick disease in a subject in need of such treatment, said method comprising:
administering to said patient a pharmaceutical formulation comprising a therapeutically effective amount of allopregnanolone and a pharmaceutically acceptable carrier.
2. The method according to claim 1 , wherein said treating comprises administering to said patient a daily dosage of allopregnanolone of from about 10 mg/kg to about 100 mg/kg.
3. The method according to claim 2 , wherein said treating comprises administering to said patient a daily dosage of allopregnanolone of from about 20 mg/kg to about 60 mg/kg.
4. The method according to claim 3 , wherein said treating comprises administering to said patient a daily dosage of allopregnanolone of about 35 mg/kg.
5. The method according to claim 1 , wherein said pharmaceutical formulation is an oral formulation.
6. The method according to claim 1 , wherein said therapeutically effective amount is administered in single or divided daily doses.
7. The method according to claim 1 , wherein said subject is not otherwise in need of treatment with allopregnanolone.