Treatment or prevention of hemorrhagic viral infections with immunomodulator compounds
View Patent ↗An immunomodulatory compound is administered to a patient having, or at risk of a hemorrhagic viral infection.
1. A method of treatment of an Arenaviridae infection in a subject comprising administering to said subject an effective amount of an immunomodulator compound of Formula A
wherein, n is 1 or 2, R is hydrogen, acyl, alkyl or a peptide fragment, and X is an aromatic or heterocyclic amino acid.
2. The method of claim 1 , wherein X is L-tryptophan or D-tryptophan.
3. The method of claim 1 wherein said compound is γ-D-glutamyl-L-tryptophan.
4. The method of claim 1 wherein said compound is administered at a dosage within a range of about 0.1-10 mg.
5. The method of claim 1 wherein said compound is administered at a dosage within a range of about 0.1-1 mg.
6. The method of claim 1 wherein said compound is administered at a dosage within a range of about 0.01-100 micrograms per kilogram subject body weight.
7. The method of claim 1 wherein said compound is administered at a dosage within a range of about 0.1-10 micrograms per kilogram subject body weight.
8. The method of claim 7 wherein said compound is γ-D-glutamyl-L-tryptophan.
9. The method of claim 1 wherein the Arenaviridae infection is selected from Lassa fever virus, Junin virus, Machupo virus, Guanarito virus, Sabia virus, Whitewater Arroyo virus or Flexal virus.
10. The method of claim 1 , wherein ribavirin is not being administered to the subject.