Tablet Comprising Branched Chain Amino Acid and Method for Producing the Same
According to the present invention, with an object to provide a tablet comprising a branched chain amino acid that can be produced without compression molding failures and a method for producing the same, provided are a tablet comprising a branched chain amino acid and hydrogenated palatinose, a method for producing a tablet comprising a branched chain amino acid in which a mixture of the branched chain amino acid and hydrogenated palatinose is compression-molded by direct tableting method, and a method for producing a tablet comprising a branched chain amino acid including a step of granulating a mixture comprising the branched chain amino acid and hydrogenated palatinose and a subsequent step of compression molding.
1 . A tablet comprising a branched chain amino acid and hydrogenated palatinose.
2 . The tablet according to claim 1 , comprising 0.1 to 6 parts by mass of the hydrogenated palatinose with respect to 1 part by mass of the branched chain amino acid.
3 . The tablet according to claim 1 or 2 , wherein the tablet has a tablet hardness of 20 to 200 N.
4 . The tablet according to claim 3 , wherein hydrogenated palatinose comprises particles having a volume average particle diameter of 0.5 to 400 μm.
5 . The tablet according to claim 4 , further comprising cellulose.
6 . The tablet according to claim 5 , wherein the cellulose comprises microcrystalline cellulose particles having a volume average particle diameter of 20 to 100 μm.
7 . The tablet according to claim 4 , wherein the branched chain amino acid comprises 10 to 80% of the tablet mass.
8 . The tablet according to claim 5 , wherein the branched chain amino acid is valine.
9 . The tablet according to claim 5 , wherein the branched chain amino acid is leucine.
10 . The tablet according to claim 5 , wherein the branched chain amino acid is isoleucine.
11 . The tablet according to claim 5 , wherein the branched chain amino acid is a mixture of valine, leucine and isoleucine.
12 . The tablet according to claim 11 , wherein the weight ratio of valine, leucine and isoleucine is 1:(0.6 to 6):(0.3 to 3), wherein the cellulose comprises microcrystalline cellulose particles having a volume average particle diameter of 20 to 100 μm, and wherein the branched chain amino acid comprises 10 to 80% of the tablet mass.
13 . The tablet according to claim 12 , wherein the tablet comprises substantially no lubricant.
14 . A method for producing a tablet comprising a branched chain amino acid according to claim 1 , which comprises compression molding a mixture comprising the branched chain amino acid and hydrogenated palatinose by direct tableting method.
15 . A method for producing a tablet comprising a branched chain amino acid according to claim 1 , which comprises granulating a mixture comprising the branched chain amino acid and hydrogenated palatinose and compression molding resulting granules.
16 . The tablet according to claim 6 , wherein the branched chain amino acid comprises 10 to 80% of the tablet mass.