Preventive and/or Therapeutic Agent for Chronic Sinusitis
The present invention provides a preventive and/or therapeutic agent and the like for chronic sinusitis, which comprises, as an active ingredient, a dibenzo[b,e]oxepine derivative represented by formula (I): (wherein R 1 , R 2 , and R 3 may be the same or different and each represents a hydrogen atom or lower alkyl, and m and n may be the same or different and each represents an integer of 1 to 4) or a pharmaceutically acceptable salt thereof.
1 . A preventive and/or therapeutic agent for chronic sinusitis, which comprises, as an active ingredient, a dibenzo[b,e]oxepine derivative represented by formula (I):
(wherein R 1 , R 2 , and R 3 independently represent a hydrogen atom or lower alkyl, and m and n independently represent an integer of 1 to 4) or a pharmaceutically acceptable salt thereof.
2 . A preventive and/or therapeutic agent for chronic sinusitis, which comprises, as an active ingredient, (Z)-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]oxepine-2-acetic acid represented by formula (IA):
or a pharmaceutically acceptable salt thereof.
3 . A process for preventing or treating chronic sinusitis comprising administering an effective amount of the compound or salt according to claim 1 or 2 to a patient in need thereof, wherein the chronic sinusitis is allergic chronic sinusitis.
4 . A process for preventing or treating chronic sinusitis comprising administering an effective amount of the compound or salt according to claim 1 or 2 to a patient in need thereof, wherein the chronic sinusitis is nonallergic chronic sinusitis.
5 - 6 . (canceled)
7 . A process for preventing or treating a symptom of chronic sinusitis comprising administering an effective amount of the compound or salt according to claim 1 or 2 to a patient in need thereof, wherein the chronic sinusitis is allergic chronic sinusitis.
8 . A process for preventing or treating a symptom of chronic sinusitis comprising administering an effective amount of the compound or salt according to claim 1 or 2 to a patient in need thereof, wherein the chronic sinusitis is nonallergic chronic sinusitis.
9 . A process for preventing or treating a symptom of chronic sinusitis comprising administering an effective amount of the compound or salt according to claim 1 or 2 to a patient in need thereof, wherein the symptom is swelling of the inside wall of the nasal cavity.
10 . A process for preventing or treating a symptom of chronic sinusitis according to claim 1 or 2 to a patient in need thereof, wherein the symptom is nasal drip.
11 . A process for preventing or treating a symptom of chronic sinusitis comprising administering an effective amount of the compound or salt according to claim 1 or 2 to a patient in need thereof, wherein the symptom is postnasal drip.
12 . A process for preventing or treating a symptom of chronic sinusitis comprising administering an effective amount of the compound or salt according to claim 1 or 2 to a patient in need thereof, wherein the symptom is a headache.
13 . A process for preventing or treating a symptom of chronic sinusitis comprising administering an effective amount of the compound or salt according to claim 1 or 2 to a patient in need thereof, wherein the symptom is a facial pain.
14 . A process for preventing or treating a symptom of chronic sinusitis comprising administering an effective amount of the compound or salt according to claim 1 or 2 to a patient in need thereof, wherein the symptom is nasal mucosal expansion.
15 . A process for preventing or treating a symptom of chronic sinusitis comprising administering an effective amount of the compound or salt according to claim 1 or 2 to a patient in need thereof, wherein the symptom is nasal obstruction.
16 . A process for preventing or treating a symptom of chronic sinusitis comprising administering an effective amount of the compound or salt according to claim 1 or 2 to a patient in need thereof, wherein the symptom is inflammation recognized as a shadow in a plain radiograph.
17 . A process for preventing or treating a symptom of chronic sinusitis comprising administering an effective amount of the compound or salt according to claim 1 or 2 to a patient in need thereof, wherein the symptom is nasal mucosal thickening or a nasal polyp.
18 - 21 . (canceled)