Dialkoxy-Imidazopyridines Derivatives
The invention relates to compounds of formula 1 and to medicaments comprising these compounds.
1 . A compound of the general formula 1,
in which
R1 is 1-4C-alkoxy or 3-7C-cycloalkyl-1-4C-alkoxy,
R2 is 1-4C-alkoxy,
R3 is 1-4C-alkoxy or 1-4C-alkoxy-1-4C-alkoxy and
R4 is hydrogen or 1-4C-alkyl,
or a hydrate, salt or hydrate of a salt thereof
2 . A compound of the general formula 1 according to claim 1 , in which
R1 is methoxy or cyclopropylmethoxy,
R2 is methoxy,
R3 is methoxy, methoxy-ethoxy or methoxy-propoxy and
R4 is hydrogen or methyl,
or a hydrate, salt or hydrate of a salt thereof.
3 . A compound of the general formula 1 according to claim 1 , in which
R1 is methoxy or cyclopropylmethoxy,
R2 is methoxy,
R3 is methoxy and
R4 is hydrogen or methyl,
or a hydrate, salt or hydrate of a salt thereof.
4 . Compound A compound according to claim 1 , which is 5-methoxy-2-[(3,4-dimethoxy-2-pyridylmethyl)sulphinyl]-1H-imidazo[4,5-b]pyridine or a hydrate, salt or hydrate of a salt thereof.
5 . A compound according to claim 1 with (S)-configuration, characterized by the general formula 1a,
in which
R1 is 1-4C-alkoxy or 3-7C-cycloalkyl-1-4C-alkoxy,
R2 is 1-4C-alkoxy,
R3 is 1-4C-alkoxy or 1-4C-alkoxy-1-4C-alkoxy and
R4 is hydrogen or 1-4C-alkyl,
or a hydrate, salt or hydrate of a salt thereof.
6 . Compound A compound according to claim 5 , which is (S)-5-methoxy-2-[(3,4-dimethoxy-2-pyridylmethyl)sulphinyl]-1H-imidazo[4,5-b]pyridine or a hydrate, salt or hydrate of a salt thereof.
7 . A salt of a compound according to claim 5 , which is selected from the group consisting of (S)-5-methoxy-2-[(3,4-dimethoxy-2-pyridylmethyl)sulphinyl]-1H-imidazo[4,5-b]pyridine sodium, (S)-bis-5-methoxy-2-[(3,4-dimethoxy-2-pyridylmethyl)sulphinyl]-1H-imidazo[4,5-b]pyridine magnesium, and the hydrates thereof.
8 . A compound according to claim 1 with (R)-configuration, characterized by the general formula 1b,
in which
R1 is 1-4C-alkoxy or 3-7C-cycloalkyl-1-4C-alkoxy,
R2 is 1-4C-alkoxy,
R3 is 1-4C-alkoxy or 1-4C-alkoxy-1-4C-alkoxy and
R4 is hydrogen or 1-4C-alkyl,
or a hydrate, salt or hydrate of a salt thereof.
9 . A compound according to claim 8 , which is (R)-5-methoxy-2-[(3,4-dimethoxy-2-pyridylmethyl)sulphinyl]-1H-imidazo[4,5-b]pyridine or a hydrate, salt or hydrate of a salt thereof.
10 . A salt of a compound according to claim 8 , which is selected from the group consisting of (R)-5-methoxy-2-[(3,4-dimethoxy-2-pyridylmethyl)sulphinyl]-1H-imidazo[4,5-b]pyridine sodium, (R)-bis-5-methoxy-2-[(3,4-dimethoxy-2-pyridylmethyl)sulphinyl]-1H-imidazo[4,5-b]pyridine magnesium, and the hydrates thereof.
11 . A pharmaceutical composition comprising a compound according to claim 1 , or a hydrate, salt or hydrate of a salt thereof, together with a pharmaceutically acceptable auxiliary.
12 . A pharmaceutical composition comprising a compound according to claim 1 , or a hydrate, salt or hydrate of a salt thereof, together with a pharmaceutically acceptable auxiliary, wherein a single dose comprises from about 10 to about 100 mg of the compound of formula 1.
13 . (canceled)
14 . A compound of formula 2
in which R1, R2, R3 and R4 have the meanings given in claim 1 , or a hydrate, salt or hydrate of a salt thereof.
15 . A method of treating a gastrointestinal disorder in a patient comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula 1 according to claim 1 , or a hydrate, salt or hydrate of a salt thereof.