Generation and use of vasculogenic tumors and products derived from same
View Patent ↗Tumors can be directed into a vasculogenic program and used to regenerate tissues in a verterbrate host, identify factors originating from the tumor that are useful for tissue regeneration, and to generate such factors for use in a subject apart from the tumor itself.
1. A method for identifying a tumor product, comprising
providing a tumor characterized by a vasculogenic program;
sampling arterial influx to the tumor;
sampling venous efflux from the tumor;
measuring an amount of a composition in the influx;
measuring an amount of the composition in the efflux; and
identifying the composition as a tumor product when the amount of the composition in the efflux exceeds the amount of the composition in the influx.
2. The method of claim 1 , wherein the tumor product is selected from the group consisting of cytokines, growth factors, morphogens, angiogenesis factors, and anti-angiogenesis factors.
3. The method of claim 1 , wherein the tumor product is a cell.
4. A method for isolating a tumor product, comprising
providing an implanted tumor characterized by a vasculogenic program;
sampling venous efflux from the tumor, wherein the efflux comprises a tumor product; and
isolating the tumor product from the efflux.
5. The method of claim 4 , wherein the tumor product is selected from the group consisting of cytokines, growth factors, morphogens, angiogenesis factors, and anti-angiogenesis factors.
6. The method of claim 4 , wherein the tumor product is a cell.