Topical pharmaceutical composition for the treatment of inflammatory dermatoses
Provided is a topical pharmaceutical composition for the treatment of inflammatory dermatoses, including acne vulgaris, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of inflammatory dermatoses plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5.
1 . A method of treating an individual afflicted with an inflammatory dermatosis, comprising topically administering to a localized region affected by the inflammatory dermatosis on the individual's body surface a formulation comprised of an active agent effective in treating the inflammatory dermatosis, a pharmaceutically acceptable topical carrier, and a permeation-enhancing base, the base being present in a predetermined amount effective to enhance the flux of the active agent through the localized region of the body surface without causing damage thereto.
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