Compositions comprising zopiclone derivatives and methods of making and using the same
The invention is directed to racemic and stereomerically pure compounds of Formula 3: and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation.
1. An enantiomerically pure compound of Formula 3:
or a pharmaceutically acceptable salt, solvate, hydrate or prodrug thereof, wherein: X is O; R 1 and R 1′ are both H or when taken together are ═O; and R 2 and R 2′ are both H or when taken together are ═O.
2. The compound of claim 1 , wherein X is O and R 1 , R 1′ , R 2 and R 2′ are all H.
3. A compound selected from the following:
or a pharmaceutically acceptable salt, solvate, hydrate or prodrug thereof.
4. A pharmaceutical composition comprising a compound of Formula 3:
or a pharmaceutically acceptable salt, solvate, hydrate or prodrug thereof, wherein: X is O; R 1 and R 1′ are both H or when taken together are ═O; and R 2 and R 2′ are both H or when taken together are ═O.
5. The pharmaceutical composition of claim 4 wherein X is O and R 1 , R 1′ , R 2 and R 2′ are all H.
6. The pharmaceutical composition of claim 4 wherein the compound of Formula 3 is stereomerically pure.