4-alkoxy cyclohexane-1 amino carboxylic acid esters and method for the production thereof
View Patent ↗The invention relates to novel 4-alkoxy-cyclohexane-1-amino-carboxylic esters of the formula (IV) in which R 1 and R 2 are as defined in the description, to intermediates and processes for their preparation and to their use as intermediates in the synthesis of insecticidal, acaricidal and herbicidal compounds or pharmaceutically active compounds.
1. Compounds of the formula (III)
in which
R 1 represents OR 3 , and
R 3 represents alkyl.
2. Compounds of the formula (III-a)
in which
R 1 is as defined in claim 1 above.
3. Compounds of the formula (III-b)
in which
R 1 is as defined in claim 1 above.
4. Process for preparing compounds of the formula (III),
in which
R 1 is as defined in claim 1 above,
characterized in that compounds of the formula (II)
in which
R 1 is as defined in claim 1 above
are reacted with ammonium carbonate and alkali metal cyanides or trimethylsilyl cyanide (TMSCN) in the solvent water.
5. Process for preparing compounds of the formula (III-a),
in which
R 1 is as defined in claim 1 above,
characterized in that compounds of the formula (II)
in which
R 1 is as defined in claim 4 above
are reacted with an alkali metal cyanide and ammonium carbonate in water.
6. Process for isolating compounds of the formula (III-a)
in which
R 1 is as defined in claim 1 above,
characterized in that compounds of the formula (III)
in which
R 1 is as defined in claim 1 above,
are treated with aqueous ammonia.