Isolated and fixed micro and nano structures and methods thereof
Discrete micro and nanoscale particles are formed in predetermined shapes and sizes and predetermined size dispersions. The particles can also be attached to a film to form arrays of particles on a film. The particles are formed from molding techniques that can include high throughput and continuous particle molding.
1. A delivery device, comprising:
a dissolvable substrate of a first material, wherein the dissolvable substrate is dissolvable in biological tissues; and
a plurality of substantially monodisperse particles configured from a second material; each particle of the plurality comprising:
a predetermined, non-spherical three-dimensional geometric solid shape;
parallel lateral surfaces and parallel top and bottom surfaces in cross-section; and
a maximum cross-sectional dimension of less than about 10 micrometers; wherein
the plurality of substantially monodisperse particles are coupled with the dissolvable substrate in a substantially predetermined orientation.
2. The delivery device of claim 1 , wherein the maximum cross-sectional dimension is between about 5 nanometers and about 5 micrometers.
3. The delivery device of claim 1 , wherein the maximum cross-sectional dimension is between about 10 nanometers and about 2 micrometers.
4. The delivery device of claim 1 , wherein the maximum cross-sectional dimension is between about 10 nanometers and about 1 micrometer.
5. The delivery device of claim 1 , wherein the maximum cross-sectional dimension is less than about 1 micrometer.
6. The delivery device of claim 1 , wherein the maximum cross-sectional dimension is less than about 750 nanometers.
7. The delivery device of claim 1 , wherein the maximum cross-sectional dimension is less than about 500 nanometers.
8. The delivery device of claim 1 , wherein the maximum cross-sectional dimension is less than about 300 nanometers.
9. The delivery device of claim 1 , wherein the maximum cross-sectional dimension is less than about 250 nanometers.
10. The delivery device of claim 1 , wherein the maximum cross-sectional dimension is less than about 200 nanometers.
11. The delivery device of claim 1 , wherein the maximum cross-sectional dimension is less than about 150 nanometers.
12. The delivery device of claim 1 , wherein the maximum cross-sectional dimension is less than about 100 nanometers.
13. The delivery device of claim 1 , wherein the second material comprises an organic material.
14. The delivery device of claim 1 , wherein the second material comprises an imaging agent.
15. The delivery device of claim 1 , wherein the second material comprises a drug.
16. The delivery device of claim 1 , wherein the second material comprises a treatment agent.
17. The delivery device of claim 1 , wherein the second material comprises an antibiotic.
18. The delivery device of claim 1 , wherein the second material comprises biologic material.
19. The delivery device of claim 1 , wherein the second material comprises a soluble material.
20. The delivery device of claim 1 , wherein the second material comprises a biodegradable material.
21. The delivery device of claim 1 , wherein the second material comprises a hydrophilic material.
22. The delivery device of claim 1 , wherein the second material comprises a hydrophobic material.
23. The delivery device of claim 1 , wherein the second material comprises an inorganic material.
24. The delivery device of claim 1 , wherein the second material comprises a polymer material.
25. The delivery device of claim 1 , wherein the second material comprises a small molecule.
26. The delivery device of claim 1 , wherein the first material and the second material comprise the same composition.
27. The delivery device of claim 1 , wherein said delivery device has a modulus from about 0.1 MPa to about 500 MPa.
28. The delivery device of claim 1 , wherein delivery device has a modulus of about 1 MPa to about 100 MPa.
29. The delivery device of claim 1 , wherein the second material comprises a porogen.
30. The delivery device of claim 1 , wherein the second material comprises a thermoplastic material.
31. The delivery device of claim 1 , wherein the dissolvable substrate comprises a thickness of about twice a dimension of a particle of the plurality of particles.
32. The delivery device of claim 1 , wherein the dissolvable substrate comprises a thickness of about equal a dimension of a particle of the plurality of particles.
33. The delivery device of claim 1 , wherein the dissolvable substrate comprises a thickness of about one half a dimension of a particle of the plurality of particles.
34. The delivery device of claim 1 , further comprising particles of more than one size coupled with the dissolvable substrate.
35. The delivery device of claim 1 , further comprising particles of more than one shape coupled with the dissolvable substrate.
36. The delivery device of claim 1 , further comprising an agent configured to couple the plurality of substantially monodisperse particles to the dissolvable substrate, wherein the agent is selected from the group consisting of covalent bonding, ionic bonding, electrostatic binding, surface energy, hydrogen bonding, van der Waals forces, other intra- and inter-molecular forces, adhesives, and a magnetic force.
37. A method of fabricating a delivery device of claim 1 , comprising:
placing a first material into a plurality of recesses in a polymer mold, wherein each recess is less than about 10 micrometers in a maximum cross-sectional dimension;
hardening the first material to form a plurality of substantially monodisperse particles, each particle of the plurality comprising a predetermined, non-spherical geometric solid shape substantially corresponding to the recess and parallel lateral surfaces and parallel top and bottom surfaces in cross-section;
removing the plurality of substantially monodisperse particles from the recesses; and
coupling the plurality of substantially monodisperse particles with a dissolvable substrate,
wherein the dissolvable substrate is dissolvable in biological tissues; and
the plurality of substantially monodisperse particles are arranged in a substantially predetermined orientation.
38. The method of claim 37 , wherein the maximum cross-sectional dimension is between about 5 nanometers and about 5 micrometers.
39. The method of claim 37 , wherein the maximum cross-sectional dimension is between about 10 nanometers and about 2 micrometers.
40. The method of claim 37 , wherein the maximum cross-sectional dimension is between about 10 nanometers and about 1 micrometer.
41. The method of claim 37 , wherein the maximum cross-sectional dimension is less than about 1 micrometer.
42. The method of claim 37 , wherein the maximum cross-sectional dimension is less than about 750 nanometers.
43. The method of claim 37 , wherein the maximum cross-sectional dimension is less than about 500 nanometers.
44. The method of claim 37 , wherein the maximum cross-sectional dimension is less than about 300 nanometers.
45. The method of claim 37 , wherein the maximum cross-sectional dimension is less than about 250 nanometers.
46. The method of claim 37 , wherein the maximum cross-sectional dimension is less than about 200 nanometers.
47. The method of claim 37 , wherein the maximum cross-sectional dimension is less than about 150 nanometers.
48. The method of claim 37 , wherein the maximum cross-sectional dimension is less than about 100 nanometers.
49. The delivery device of claim 1 , wherein said plurality of substantially monodisperse particles are arranged in a substantially ordered array.
50. The delivery device of claim 1 , wherein said dissolvable substrate is a sugar-based dissolvable film.
51. The delivery device of claim 50 , wherein said film is a sugar sheet comprising pullulan, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl pyrrolidone, carboxymethyl cellulose, polyvinyl alcohol, sodium alginate, polyethylene glycol, xanthan gum, tragacanth gum, guar gum, acacia gum, arabic gum, polyacrylic acid, methylmethacrylate copolymer, carboxyvinyl polymer, amylose, high amylose starch, hydroxypropylated high amylose starch, dextrin, pectin, chitin, chitosan, levan, elsinan, collagen, gelatin, zein, gluten, soy protein isolate, whey protein isolate and/or casein, or combinations thereof.