Formulations of fispemifene
This invention relates to a liquid or semisolid oral drug formulation comprising a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a mixture of isomers, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, in combination with a pharmaceutically acceptable carrier.
1 . A liquid or semisolid oral drug formulation comprising a therapeutically active compound of the formula (I)
or a geometric isomer, a stereoisomer, a mixture of isomers, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, in combination with a pharmaceutically acceptable carrier.
2 . The drug formulation according to claim 1 wherein compound (I) is fispemifene.
3 . The drug formulation according to claim 1 wherein said formulation is selected from the group consisting of a solution, a suspension and a combination of a solution and suspension.
4 . The drug formulation according to claim 1 wherein said therapeutically active compound is dissolved and/or suspended in an oil.
5 . The drug formulation according to claim 1 wherein said formulation is an emulsion.
6 . The drug formulation according to claim 5 wherein the emulsion is a microemulsion or nanoemulsion.
7 . The drug formulation according to claim 1 wherein the formulation is a syrup.
8 . The drug formulation according to claim 1 wherein the formulation is a gel.
9 . The drug formulation according to claim 1 wherein the formulation is a paste.
10 . The drug formulation according to claim 1 wherein said formulation is packed into a unit dosage form.
11 . The drug formulation according to claim 10 wherein the dosage form is the formulation encapsulated in a soft capsule.
12 . The drug formulation according to claim 1 wherein the carrier comprises a bile flow promoting agent.