Metal-binding therapeutic peptides
View Patent ↗The present invention is related methods of delivering MBD peptide-linked agents into live cells. The methods described herein comprise contacting MBD peptide-linked agents to live cells under a condition of cellular stress. The methods of the invention may be used for therapeutic or diagnostic purposes.
1. A polypeptide comprising the amino acid sequence ETFSDLWKLLKKGFYKKKQCRPSKGRKRGFCW (SEQ ID NO:16).
2. A composition comprising the polypeptide of claim 1 and a pharmaceutical excipient.
3. A nucleic acid encoding the polypeptide of claim 1 .
4. A vector comprising the nucleic acid of claim 3 .
5. A polypeptide comprising the amino acid sequence ETFSDVWKLLKKGFYKKKQCRPSKGRKRGFCW (SEQ TD NO:17).
6. A composition comprising the polypeptide of claim 5 and a pharmaceutical excipient.
7. A nucleic acid encoding the polypeptide of claim 5 .
8. A vector comprising the nucleic acid of claim 7 .
9. A polypeptide comprising the amino acid sequence ETFSDJWKLLKKGFYKKKQCRPSKGRKRGFCW (SEQ ID NO:18).
10. A composition comprising the polypeptide of claim 9 and a pharmaceutical excipient.
11. A nucleic acid encoding the polypeptide of claim 9 .
12. A vector comprising the nucleic acid of claim 11 .