Genetic products differentially expressed in tumors and the use thereof
According to the invention, gene products expressed in a tumor-associated manner and the nucleic acids coding therefor were identified. The invention relates to the therapy and diagnosis of diseases wherein said gene products expressed in a tumor-associated manner are aberrantly expressed. The invention also relates to proteins, polypeptides and peptides which are expressed in a tumor associated manner and to nucleic acids coding therefor.
1. A method of treating a disease characterized by expression of a tumor-associated antigen that (a) is encoded by a nucleic acid which comprises a nucleic acid sequence of SEQ ID NO: 7 or (b) comprises the amino acid sequence of SEQ ID NO: 16, comprising administering to a patient suffering from said disease an antibody that selectively binds to the tumor-associated antigen, wherein said disease is lung tumor or a pancreatic tumor.
2. The method of claim 1 wherein the disease is a lung tumor.
3. The method according to claim 1 , wherein the antibody is selected from the group consisting of a monoclonal antibody, a chimeric antibody, a humanized antibody, a combination of any of the foregoing, and an immunoreactive fragment of any of the foregoing.
4. The method according to claim 1 wherein the antibody is coupled to a therapeutic agent.
5. The method according to claim 4 wherein the therapeutic agent is an anticancer agent, a toxin, a radioactive compound or a cytostatic or cytolytic compound.
6. The method according to claim 1 wherein the binding of the agent causes a cytolytic reaction and/or induces cytokine release.
7. The method of claim 1 wherein the disease is a pancreatic tumor.