Biocompatible material
View Patent ↗A biocompatible material having excellent biocompatibility such as small interaction with a component of a living body such as a protein or blood cell. A biocompatible material comprising a polymer obtained by polymerizing a monomer composition comprising an amino acid-type betaine monomer represented by the formula (I): wherein R 1 is a hydrogen atom or a methyl group; R 2 is an alkylene group having 1 to 6 carbon atoms; each of R 3 and R 4 is independently an alkyl group having 1 to 4 carbon atoms; R 5 is an alkylene group having 1 to 4 carbon atoms; and Z is an oxygen atom or an —NH group; and a polymerizable monomer represented by the formula (II): wherein R 1 is as defined above; and R 6 is a monovalent organic group, in a weight ratio, i.e. amino acid-type betaine monomer/polymerizable monomer, of from 1/99 to 100/1. The biocompatible material can be suitably used, for example, in food, a food additive, a medicament, a quasi-drug, a medical device, cosmetics, a toiletry article, or the like.
1. A medical device comprising a biocompatible material comprising a polymer obtained by polymerizing
a monomer composition comprising an amino acid-type betaine monomer represented by the formula (I):
wherein R 1 is a hydrogen atom or a methyl group; R 2 is an alkylene group having 1 to 6 carbon atoms; each of R 3 and R 4 is independently an alkyl group having 1 to 4 carbon atoms; R 5 is an alkylene group having 1 to 4 carbon atoms; and Z is an oxygen atom or an —NH group; and
a polymerizable monomer represented by the formula (II):
wherein R 1 is as defined above; and R 6 is a monovalent organic group,
in a weight ratio of amino acid-type betaine monomer/polymerizable monomer of from 1/99 to 100/0,
wherein said medical device is selected from the group consisting of artificial blood vessels, blood dialysis membranes, catheters, blood filters, blood storage bags, and artificial organs.
2. The medical device according to claim 1 , wherein the amino acid-type betaine monomer is N-methacryloyloxyethyl-N,N-dimethylammonium-α-N-methylcarboxybetaine represented by the formula (III):