Remotely RF powered conformable thermal applicators
View Patent ↗Embodiments of the present invention are generally related to apparatus and methodology of thermal applicators in cancer therapy. In particular, the present embodiments are directed to a technique called “nanoparticle ferromagnetic resonance heating,” where ferromagnetic resonance heating in addition to an RF hyperthermia treatment is used to cause cell apoptosis and necrosis. An apparatus for carrying out a ferromagnetic resonance heating treatment of a tumor, comprises a volume concentration of super paramagnetic particles contained within the interior of the tumor, the concentration ranging from about 0.1 to about 1 percent; a magnetic field source configured to deliver a gradient DC magnetic field to the region of the tumor; and an energy source configured to deliver to the tumor an RF field at a frequency ranging from about 100 to 200 MHz. The apparatus of claim 1 , wherein the super paramagnetic particles are selected from the group consisting of maghemite (γ-Fe 2 O 3 ) based compounds, and yttrium iron garnet (Y 3 Fe 5 O 12 ) based compounds.
1. A system for carrying out a ferromagnetic resonance heating treatment of a tumor, the system comprising:
a volume concentration of super paramagnetic particles adapted to be contained within the interior of the tumor, the concentration ranging from about 0.1 to about 1 percent;
a magnetic field source configured to deliver a gradient DC magnetic field to the region of the tumor; and
an energy source configured to deliver to the tumor an RF field at a frequency ranging from about 100 to 200 MHz.
2. The apparatus of claim 1 , wherein the super paramagnetic particles are selected from the group consisting of maghemite (γ-Fe 2 O 3 ) based compounds, and yttrium iron garnet (Y 3 Fe 5 O 12 ) based compounds.