Biodegradable T-cell Activation device
A biodegradable device for activating T-cells includes a biodegradable support and a binder attached to the biodegradable support, the binder having reactivity to one or more agents capable of binding to a T-cell surface antigen.
1. A biodegradable device for activating T-cells, the device comprising:
a biodegradable support; and
a first material attached to the biodegradable support, wherein the first material is an antibody capable of cross-linking more than one second material, the second material capable of binding to a T-cell surface antigen.
2. The biodegradable device of claim 1 wherein the biodegradable support comprises collagen, gelatin, albumen or polysaccharides.
3. The biodegradable device of claim 1 wherein the biodegradable support comprises aliphatic polyesters.
4. The biodegradable device of claim 1 wherein the second materials have reactivity to T-cell surface antigens.
5. The biodegradable device of claim 1 wherein the first material comprises polyclonal or monoclonal antibodies, or fragments thereof.
6. The biodegradable device of claim 1 wherein the first material is attached to the biodegradable support with glutaraldehyde.
7. The biodegradable device of claim 6 and further comprising diaminoheptane spacer groups.
8. The biodegradable device of claim 1 wherein the second materials include mitogenic proteins, monoclonal antibodies, fusion proteins and agents capable of binding to chemokine receptors.
9. The biodegradable device of claim 8 wherein the mitogenic proteins include anti-CD3 and anti-CD2 monoclonal antibodies.
10. The biodegradable device of claim 9 and further including co-stimulatory proteins that are specific for one or more T-cell surface molecules.