IP Library › Granted Patent US 7,786,102
Granted Patent B2
US 7,786,102 · App. 11/602,307 · Granted Aug 31, 2010

Steroids as agonists for FXR

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Quick Facts
Patent No.
US 7,786,102
App. No.
11/602,307
Granted
Aug 31, 2010
Kind
B2
Abstract

The invention relates to compounds of formula (I): wherein R is ethyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.

Claims (4)

1. A method for activating FXR in a mammal comprising administering to the mammal, in an amount effective for activating FXR, a compound:

or a pharmaceutically acceptable salt or amino acid conjugate thereof, wherein said mammal is in need of treatment of an FXR mediated disease, further wherein said disease is cholestatic liver disease.

2. The method according to claim 1 , wherein the compound is a pharmaceutically acceptable salt of the compound.

3. The method according to claim 1 , wherein the compound is the amino acid conjugate of the compound.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Jan 4, 2024
From: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION
To: INTERCEPT PHARMACEUTICALS, INC.
Reel/Frame 066662/0210 →
CHANGE OF ADDRESS Recorded Aug 22, 2022
From: INTERCEPT PHARMACEUTICALS, INC.
To: INTERCEPT PHARMACEUTICALS, INC.
Reel/Frame 061297/0856 →
SECURITY INTEREST Recorded Aug 18, 2021
From: INTERCEPT PHARMACEUTICALS, INC.
To: U.S. BANK NATIONAL ASSOCIATION
Reel/Frame 057650/0772 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 29, 2010
From: PELLICCIARI, ROBERTO
To: INTERCEPT PHARMACEUTICALS, INC.
Reel/Frame 024153/0831 →