Immobilizing objects in the body
View Patent ↗Stabilizing an object in the body of a patient involves the injection of a lower critical solution temperature (LCST) material or other flowable material into the body of the patient so that the material contacts the object. The LCST material or other flowable material then forms a gel in the body such that the object is contained at least partially within the gel and thereby stabilized by the gel such that the object can then be easily fragmented within the body and/or retrieved from the body.
1. A method of stabilizing an object in a patient's body comprising:
injecting a flowable material into the patient's body, wherein said flowable material comprises a material that becomes a gel at or above about body temperature and said flowable material contacts the object before transformation into a gel form; and
stabilizing the object by forming a gel that contacts the object in the patient's body.
2. The method of claim 1 , wherein the transformation of the flowable material into a gel form causes the flowable material to form a seal or plug in the body.
3. The method of claim 1 , wherein the flowable material is cooled to a temperature below ambient air temperature prior to injection.
4. The method of claim 1 , wherein the flowable material comprises a lower critical solution temperature material.
5. The method of claim 4 , further comprising the step of contacting the lower critical solution temperature material with a degradation modulating material.
6. The method of claim 5 , wherein the degradation modulating material is selected from the group consisting of pluronic acid, polylactic acid, polyglycolic acid, and hyaluronic acid.
7. The method of claim 1 , wherein the flowable material comprises a block copolymer with reverse thermal gelation properties.
8. The method of claim 7 , wherein the block copolymer comprises a polyoxyethylene-polyoxypropylene block copolymer comprising biodegradable, biocompatible copolymers of polyethylene oxide and polypropylene oxide.
9. The method of claim 1 , wherein the flowable material is a carrier for chemical compounds, drugs, hormones, dyes, or other additives to enhance the effectiveness, safety or functionality of the gel.
10. A method of stabilizing and eliminating an object in a patient's body comprising:
injecting a flowable material into the patient's body, wherein said flowable material comprises a material that becomes a gel at or above about body temperature and said flowable material contacts the object before transformation into a gel form;
stabilizing the object by forming a gel that contacts the object in the patient's body; and
retrieving, breaking, or otherwise eliminating the object from the body.
11. The method of claim 10 , further comprising the step of: introducing a cooled fluid having a temperature of from −10° C. to 20° C. into the body to facilitate breakdown of the gel in the body.
12. The method of claim 11 , wherein the cooled fluid comprises a physiologically acceptable liquid comprising water, saline, contrast media, or fluid.
13. The method of claim 10 , wherein the step of breaking the object comprises a technique selected from the group consisting of extracorporeal shock wave lithotripsy, intra-corporeal shock wave lithotripsy, or Holmium laser fragmentation.
14. The method of claim 10 , further comprising the step of applying energy to the object causing it to break into at least two fragments.
15. The method of claim 14 , wherein the energy applied to the object is selected from the group consisting of mechanical, vibrational, light, chemical, and electromagnetic energy.
16. A system for stabilizing an object in a body of a patient comprising:
a material which remains in a flowable form below about a temperature inside the body of the patient and which forms a gel about at and above the temperature inside the body of a patient; and
a percutaneous access device for transferring the material into the patient's body in flowable form, such that the gel formed by the material contacts and thereby stabilizes the object.
17. The system of claim 16 , wherein the percutaneous access device comprises a needle.
18. The system of claim 16 , wherein the system further comprises: a catheter for removing the material from the body and a mechanism to force the material in through the percutaneous access device comprising a syringe.
19. The system of claim 16 , wherein the material comprises a block copolymer with reverse thermal gelation properties.
20. The system of claim 19 , wherein the block copolymer comprises a polyoxyethylene-polyoxypropylene block copolymer comprising biodegradable, biocompatible copolymers of polyethylene oxide and polypropylene oxide.
21. The system of claim 16 , wherein the material is a carrier for chemical compounds, drugs, hormones, dyes, or other additives to enhance the effectiveness, safety or functionality of the gel.