3-aminocyclopentanecrboxamides as modulators of chemokine receptors

1. A compound of Formula I:

or pharmaceutically acceptable salts or prodrugs thereof, wherein:

a dashed line indicates an optional bond;

W is:

V is N, NO or CR 5 ;

X is N, NO or CR 2 ;

Y is N, NO or CR 3 ;

Z is N, NO or CR 4 ; wherein no more than one of V, X, Y and Z is NO;

L is C 1-4 alkylenyl, C 2-4 alkenylenyl, C 2-4 alkynylenyl, C(O), C(O)NR 9 , S(O), S(O)NR 9 , S(O) 2 , or S(O) 2 NR 9 ;

R A , R A1 , R B and R B1 are each, Independently, H, OH, halo, C 1-6 alkyl, C 1-6 alkenyl, C 1-6 alkynyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, heterocyclyl, carbocyclyl, NR 10 R 12 , NR 10 CO 2 R 11 ; NR 10 CONR 13 R 12 , NR 10 SO 2 NR 10 R 12 , NR 10 —SO 2 —R 11 , CN, CONR 10 R 12 , CO 2 R 10 , NO 2 , SR 10 , SOR 10 , SO 2 R 10 , or SO 2 —NR 10 R 12 ;

R 1 is C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, —(C 0-6 alkyl)—O—(C 1-6 alkyl), —(C 0-6 alkyl)—S(C 1-6 alkyl), —(C 0-6 alkyl)—(C 3-7 cycloalkyl)—(C 0-6 alkyl), OH, OR 10 , SR 10 , COR 11 , CO 2 R 10 , CONR 10 R 12 , carbocyclyl, heterocyclyl, CN, NR 10 R 12 , NR 10 SO 2 R 10 , NR10COR 10 , NR 10 CO 2 R 10 , NR 10 CONR 12 , CR 10 R 11 CO 2 R 10 or CR 10 R 11 OCOR 10 ;

R 3 , R 3 , R 4 , R 5 and R 6 are each, independently, H, OH, halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 thioalkoxy, NR 10 R 12 , NR 10 CO 2 R 11 , NR 10 CONR 10 R 12 , NR 10 SO 2 NR 10 R 12 , NR 10 —SO 2 —R 11 , heterocyclyl, carbocyclyl, carbocyclyloxy, heterocyclyloxy, CN, NO 2 , COR 11 , CONR 10 R 12 , CO 2 R 10 , NO 2 , SR 10 , SOR 10 , SO 2 R 10 ; or SP 2 —NR 10 R 12 ;

R 7 is H or C 1-8 alkyl optionally substituted by 1, 2, 3, 4, 5 or 6 substituents independently selected from halo, C 1-10 haloalkyl, Cy, CN, NO 2 , OR a , C(O)R b , C(O)NR C R d , C(O)OR a , OC(O)R b , OC(O)NR C R d , NR C R d , NR C C(O)R b , NR C C(O)OR a , S(O)R b , S(O)NR C R d , S(O) 2 R b , NR C S(O) 2 R b , S(O) 2 NR c R d ; or R 7 is H, C 1-8 alkyl which is unsubstituted or substituted with 1-6 substituents selected from: hydroxy, —O—C 1-6 alkyl, —NR 12a R 12a , —NR 12a COR 13a , —NR 12a SO 2 R 14a , COR 11a , —CONR 12a R 12a , phenyl and heterocycle, where the alkyl, phenyl, and heterocycle are unsubstituted or substituted with 1-3 substituents selected from: halo, hydroxy, C 1-3 alkyl, C 1-3 alkoxy, —CO 2 H, —CO 2 —C 1-6 alkyl, trifluoromethyl, and —SO 2 C 1-6 alkyl which is unsubstituted or substituted with 1-6 substituents selected from: hydroxy, halo, —O—C 1-6 alkyl, CN, —NR 12a R 12a , NR 12a COR 13a , —NR 12a SO 2 R 14a , —COR 11a , —CONR 12a R 12a , phenyl and heterocycle, where the alkyl, phenyl, and heterocycle are unsubstituted or substituted with 1-3 substituents selected from: halo, hydroxy, C 1-3 alkyl, C 1-3 alkoxy, —CO 2 H, —CO 2 —C 1-6 alkyl, and trifluoromethyl; or R 7 is H, C 1-6 alkyl unsubstituted or substituted with 1-3 substituents selected from: halo, hydroxy, —CO 2 H, —CO 2 C 1-6 alkyl, and —O—C 1-3 alkyl;

R 8 is C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 haloalkyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl, wherein said C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 haloalkyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from oxo, hydroxy, halo, C 1-4 alkyl, C 1-4 alkoxy, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, C 1-4 cyanoalkyl, Cy′, —(C 1-4 alkyl)-Cy′, —C(O)—R a , CN, NO 2 , —(CH 2 ) q —ORa′, —(CH 2 ) q —SR a′ , —(CH 2 ) q —C(O)R b′ , —(CH 2 ) q —C(O)NR C′ R d′ , —(CH 2 ) q —C(O)OR a′ , —(CH 2 ) q —S(O)R b′ , —(CH 2 ) q —S(O) 2 R b′ , and —(CH 2 ) q —S(O) 2 NR c′ R d′ ; or R 8 is selected from C 1-10 alkyl, —SO 2 C 1-10 alkyl, pyridyl or phenyl, unsubstituted or substituted with 1-5 substituents selected from: hydroxy, halo, —O—C 1-6 alkyl, —S—C 1-6 alkyl, CN, —NR 12a R 12a , —NR 12a COR 13a , —NR 12a SO 2 R 14a , —COR 11a , —CONR 12a R 12a , —SO 2 R 14a , heterocycle, ═O (where the oxygen is connected via a double bond), phenoxy and phenyl, where the alkyl, phenyl, phenoxy and heterocycle are unsubstituted or substituted with 1-3 substituents selected from: halo, hydroxy, C 1-3 alkyl, C 1-3 alkoxy, —COR 11a , —CN, —NR 12a R 12a SO 2 R 14a , —NR 12a COR 13a , —NR 12a SO 2 R 14a , and —CONR 12a R 12a , where the alkyl and alkoxy are optionally substituted with 1-5 fluoro; or R 8 is a group of formula:

Y and Z are independently selected from —O—, —NR 12b , —S—, —SO—, —SO 2 —, —CR 12b R 12b —, NSO 2 R 14b —, —NCOR 13b —, —CR 12b COR 11b —, —CR 12b OCOR 13b —, —C— and —CO—;

R 8a is selected from: hydrogen, C 1-6 alkyl unsubstituted or substituted with 1-6 substituents selected from fluoro, C 1-3 alkoxy, hydroxy and —COR 11b , fluoro, —O—C 3 alkyl unsubstituted or substituted with 1-3 fluoro, C 3-6 cycloalkyl, —O—C 3-6 cycloalkyl, hydroxy, —COR 11b , —OCOR 13b ; or R 7 and R 8a together are C 2-4 alkyl or C 0-2 alkyl-O—C 1-3 alkyl, forming a 5-7 membered ring;

R 9a is selected from: hydrogen, C 1-6 alkyl unsubstituted or substituted with 1-6 substituents selected from fluoro, C 1-3 alkoxy, hydroxy and —COR 11b , COR 11b , hydroxy and —O—C 1-6 alkyl unsubstituted or substituted with 1-6 substituents selected from fluoro, C 1-3 alkoxy, hydroxy and —COR 11b ;

or R 8a and R 9a together are C 1-4 alkyl or C 0-3 alkyl-O—C 0-3 alkyl, forming a 3-6 membered ring;

R 10a is selected from: hydrogen, hydroxy, C 1-6 alkyl unsubstituted or substituted with 1-6 fluoro, fluoro, —O—C 3-6 cycloalkyl and —O—C 1-3 alkyl unsubstituted or substituted with 1-6 fluoro;

or R 8a and R 10a together are C 2-3 alkyl, forming a 5-6 membered ring, where said alkyl is unsubstituted or substituted with 1-3 substituents independently selected from halo, hydroxy, COR 11b , C 1-3 alkyl and C 1-3 alkoxy;

or R 8a and R 10a together are O—C 1-2 alkyl-O-C 1-2 alkyl, forming a 6-8 membered ring, where said alkyl is unsubstituted or substituted with 1-3 substituents independently selected from halo, hydroxy, —COR 11b , C 1-3 alkyl and C 1-3 alkoxy;

or R 8a and R 10a together are —O—C 1-2 alkyl-O—, forming a 6-7 membered ring, where said alkyl is unsubstituted or substituted with 1-3 substituents independently selected from halo, hydroxy, —COR 11b , C 1-3 allyl and C 1-3 alkoxy;

R 11a and R 11b are independently selected from: hydroxy, hydrogen, C 1-6 alkyl, —O—C 1-6 allyl, benzyl, phenyl and C 3-6 cycloalkyl, where said alkyl, phenyl, benzyl and cycloalkyl groups are unsubstituted or substituted with 1-3 substituents independently selected from halo, hydroxy, C 1-3 alkyl, C 1-3 alkoxy, —CO 2 H, —CO 2 —C 1-6 alkyl, and trifluoromethyl;

R 12a and R 12b are independently selected from: hydrogen, hydroxy, C 1-6 alkyl, benzyl, phenyl, C 3-6 cycloalkyl, where the alkyl, phenyl, benzyl, and cycloalkyl groups are unsubstituted or substituted with 1-3 substituents independently selected from: halo, hydroxy, C 1-3 alkyl, C 1-3 alkoxy, CO 2 H, —CO 2 —C 1-6 alkyl, and trifluoromethyl; or R 12a and R 12b are selected from: C 1-6 alkyl unsubstituted or substituted with 1-6 substituents selected from fluoro, C 1-3 alkoxy, hydroxy and COR 11b , fluoro, —O—C 1-3 alkyl unsubstituted or substituted with 1-6 fluoro, C 3-6 cycloalkyl, —O—C 3-6 cycloalkyl, hydroxy, —O—C 1-6 alkyl unsubstituted or substituted with 1-6 substituents selected from fluoro, C 1-3 alkoxy, hydroxy and —COR 11b ;

R 13a and R 13b are independently selected from: hydrogen, C 1-6 alkyl, —O—C 1-6 alkyl, benzyl, phenyl, C 3-6 cycloalkyl, where the alkyl, phenyl, benzyl, and cycloalkyl groups are unsubstituted or substituted with 1-3 substituents independently selected from: halo, hydroxy, C 1-3 alkyl, C 1-3 alkoxy, —CO 2 H, —CO 2 —C 1-6 alkyl, and trifluoromethyl;

R 14a and R 14b are independently selected from: hydroxy, C 1-6 alkyl, —O—C 1-6 alkyl, benzyl, phenyl, C 3-6 cycloalkyl, where the alkyl, phenyl, benzyl, and cycloalkyl groups are unsubstituted or substituted with 1-3 substituents independently selected from: halo, hydroxy, C 1-3 alkyl, C 1-3 alkoxy, CO 2 H, —CO 2 —C 1-6 alkyl, and trifluoromethyl;

Cy and Cy′ are, independently, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, each optionally substituted by 1,2,3,4 or 5 substituents independently selected from oxo, hydroxy, halo, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, CN, NO 2 , OR a″ , SR a″ , C(O)R b″ , C(O)NR C″ R d″ , C(O)OR a″ , OC(O)R b″ , OC(O)NR C″ R d″ , NR c″ R d″ , NR C″ C(O)R b″ , NR C″ C(O)OR a″ , S(O)R b″ , S(O)NR C″ R d″ , S(O) 2 R b″ , and S(O) 2 NR C″ R d″ , aryl, or heteroaryl, cycloalkyl, or heterocycloalkyl;

R 9 is H, C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, or C 2-6 alkynyl, wherein said C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, or C 2-6 alkynyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

R 10 is H, C 1-6 alkyl, benzyl, phenyl, or C 3-6 cycloalkyl, wherein said C 1-6 alkyl, benzyl, phenyl, or C 3-6 cycloalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from halo, OH, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, CO 2 H, and CO 2 —(C 1-6 alkyl);

R 11 is H, OH, C 1-6 alkyl, C 1-6 alkoxy, benzyl, phenyl, benzyloxy, phenyloxy, C 3-6 cycloalkyl or C 3-6 cycloalkyloxy, wherein said C 1-6 alkyl, C 1-6 alkoxy, benzyl, phenyl, benzyloxy, phenyloxy, C 3-6 cycloalkyl or C 3-6 cycloalkyloxy, is optionally substituted with 1, 2 or 3 substituents independently selected from halo, OH, C 1-3 alkyl, C 1-3 alkoxy, CO 2 H, CO 2 —(C 1-6 alkyl) and CF 3 ;

R 12 is H, C 1-6 alkyl, benzyl, phenyl, or C 3-6 cycloalkyl, wherein said C 1-6 alkyl, benzyl, phenyl, or C 3-6 cycloalkyl is optionally substituted with 1,2, or 3 substituents independently selected from halo, OH, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, CO 2 H, and CO 2 —(C 1-6 alkyl);

R a , R a′ and R a″ are, independently, H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C 1-6 alkyl,

C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

R b , R b′ and R b″ are, independently, H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl,

C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

R C and R d are, independently, H, C 1-10 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl,

C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

or R C and R d together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

R c , and R d′ are, independently, H, C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

or R C′ and R d′ together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

R C″ and R d″ are, independently, H, C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

or R C″ and R d″ together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

m is 0, 1, or 2;

n is 1;

p is 0 or 1; and

q is 0, 1, 2, or 3.

2. A compound of Formula I:

or pharmaceutically acceptable salt thereof, wherein:

a dashed line indicates an optional bond;

W is:

V is N, NO or CR 5 ;

X is N, NO or CR 2 ;

Y is N, NO or CR 3 ;

Z is N, NO or CR 4 ; wherein no more than one of V, X, Y and Z is NO;

L is C 1-4 alkylenyl, C 2-4 alkenylenyl, C 2-4 alkynylenyl, C(O), C(O)NR 9 , S(O), S(O 2 NR 9 , S(O) 2 , or S(O) 2 NR 9 ;

R A , R A1 , R B and R B1 are each, independently, H, OH, halo, C 1-6 alkyl, C 1-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, heterocyclyl, carbocyclyl, NR 10 R 12 , NR 10 CO 2 R 11 ; NR 10 CONR 10 R 12 , NR 10 SO 2 NR 10 R 12 , NR 10 —SO 2 —R 11 , CN, CONR 10 R 12 , CO 2 R 10 , NO 2 , SR 10 , SOR 10 , SO 2 R 10 , or SO 2 —NR 10 R 12 ;

R 1 is C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, —(C 0-6 alkyl)-O—(C 1-6 alkyl), —(C 0-6 alkyl)-S(C 1-6 alkyl), —(C 0-6 alkyl)-(C 3-7 cycloalkyl)-(C 0-6 alkyl), OH, OR 10 , SR 10 , COR 11 , CO 2 R 10 , CONR 10 R 12 , carbocyclyl, heterocyclyl, CN, NR 10 R 12 , NR 10 SO 2 R 10 , NR 10 COR 10 , NR 10 CO 2 R 10 , NR 10 CONR 12 , CR 10 R 11 CO 2 R 10 or CR 10 R 11 OCOR 10 ;

R 2 , R 3 , R 4 , R 5 and R 6 are each, independently, H, OH, halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 thioalkoxy, NR 10 R 12 , NR 10 CO 2 R 11 , NR 10 CONR 10 R 12 , NR 10 SO 2 NR 10 R 12 , NR 10 —SO 2 —R 11 , heterocyclyl, carbocyclyl, carbocyclyloxy, heterocyclyloxy, CN, NO 2 , COR 11 , CONR 10 R 12 , CO 2 R 10 , NO 2 , SR 10 , SO 2 R 10 , SO 2 R 10 ; or SO 2 —NR 10 R 12 ;

R 7 is H or C 1-8 alkyl optionally substituted by 1, 2, 3, 4, 5 or 6 substituents independently selected from halo, C 1-10 haloalkyl, Cy, CN, NO 2 , OR a , C(O)R b , C(O)NR C R d , C(O)OR a , OC(O)R b , OC(O)NR C R d , NR c R d , NR C C(O)R b , NR C C(O)NR d NR C C(O)OR a , S(O)R b , S(O)NR C R d , S(O) 2 R b , NR C S(O) 2 R b , and S(O) 2 NR C R d ;

R 8 is C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 haloalkyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl, wherein said C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-10 haloalkyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from halo, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, C 1-4 cyanoalkyl, Cy′, —(C 1-4 alkyl)-Cy′, CN, NO 2 , —(CH 2 ) q —OR a′ , —(CH 2 ) q —SR a′ , —(CH 2 ) q —C(O)R b′ , —(CH 2 ) q -C(O)NR c′ R d′ , —(CH 2 ) q C(O)OR a′ , —(CH 2 ) q OC(O)R b′ , —(CH 2 ) q —OC(O)NR c′ R d′ , —(CH 2 ) q —NR c′ R d′ , —(CH 2 ) q —NR c′ C(O)OR a′ , —(CH 2 ) q OC(O)R b′ , —(CH 2 ) q —NR c′ C(O)OR a′ , —(CH 2 ) q —S(O)R b′ , —(CH 2 ) q —S(O)NR c′ R d′ , —(CH 2 ) q —S(O) 2 R b′ , —(CH 2 ) q NR c′ S(O) 2 R b , and —(CH 2 ) g S(O) 2 NR c′ R d′ ;

Cy and Cy′ are, independently, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, each optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, CN, NO 2 , OR a″ , SR a″ , C(O)R b″ , C(O)NR c″ R d″ , C(O)OR a″ , OC(O)R b″ , OC(O)NR C″ R d″ , NR c″ R d″ , NR C″ C(O)R b″ , NR C″ C(O)OR a″ , S(O)R b″ , S(O)NR C″ R d″ , S(O) 2 R b″ , and S(O) 2 NR C″ R d″ ;

R 9 is H, C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, or C 2-6 alkynyl, wherein said C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, or C 2-6 alkynyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

R 10 is H, C 1-6 alkyl, benzyl, phenyl, or C 3-6 cycloalkyl, wherein said C 1-6 alkyl, benzyl, phenyl, or C 3-6 cycloalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from halo, OH, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy,

C 1-3 haloalkoxy, CO 2 H, and CO 2 —(C 1-6 alkyl);

R 11 is H, OH, C 1-6 alkyl, C 1-6 alkoxy, benzyl, phenyl, benzyloxy, phenyloxy, C 3-6 cycloalkyl or C 3-6 cycloalkyloxy, wherein said C 1-6 alkyl, C 1-6 alkoxy, benzyl, phenyl, benzyloxy, phenyloxy, C 3-6 cycloalkyl or C 3-6 cycloalkyloxy, is optionally substituted with 1, 2 or 3 substituents independently selected from halo, OH, C 1-3 alkyl, C 1-3 alkoxy, COY, CO 2 —(C 1-6 alkyl) and CF 3 ;

R 12 is H, C 1-6 alkyl, benzyl, phenyl, or C 3-6 cycloalkyl, wherein said C 1-6 alkyl, benzyl, phenyl, or C 3-6 cycloalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from halo, OH, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, CO 2 H, and CO 2 —(C 1-6 alkyl);

R a , R a′ and R a″ are, independently, H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

R b , R b′ , and R b″ are, independently, H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

R C and R d are, independently, H, C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl wherein said C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

or R C and R d together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

R c′ and R d′ are, independently, H, C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

or R C′ and R d′ together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

R C″ and R d′ are, independently, H, C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C 1-10 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

or R C″ and R d″ together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl;

n is 0 or 1;

p is 0 or 1; and

q is 0, 1, 2, or 3;

wherein when n is 0, R 8 is other than substituted or unsubstituted tetrahydropyran-4-yl.

3. The compound of claim 1 wherein W is

4. The compound of claim 1 wherein W is

5. The compound of claim 1 wherein V is CR 5 .

6. The compound of claim 1 wherein X is CR 2 .

7. The compound of claim 1 wherein Y is CR 3 .

8. The compound of claim 1 wherein Z is CR 4 .

9. The compound of claim 1 wherein X is CR 2 ; Y is CR 3 ; and Z is CR 4 .

10. The compound of claim 1 wherein V is CR 5 ; X is CR 2 ; Y is CR 3 ; and Z is CR 4 .

11. The compound of claim 1 wherein R A , R A1 , R B and R B1 are each, independently H, OH, halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy or C 1-6 haloalkoxy.

12. The compound of claim 1 wherein R A , R A1 , R B and R B1 are each, independently H, OH, halo, or C 1-6 alkoxy.

13. The compound of claim 1 wherein R A , R A1 , R B and R B1 are each, independently H or OH.

14. The compound of claim 1 wherein R 1 is C 1-6 alkyl, C 1-6 hydroxyalkyl, —(C 0-6 alkyl)-O—(C 1-6 allyl), or heterocyclyl.

15. The compound of claim 1 wherein R 1 is C 1-6 alkyl.

16. The compound of claim 1 wherein R 1 is prop-2-yl.

17. The compound of claim 1 wherein one of R 5 and R 6 is other than H.

18. The compound of claim 1 wherein one of R 5 and R 6 is C 1-4 haloalkyl.

19. The compound of claim 1 wherein R 6 is C 1-4 haloalkyl.

20. The compound of claim 1 wherein R 6 is CF 3 .

21. The compound of claim 1 wherein R 7 is H.

22. The compound of claim 1 wherein R 1 is C 1-8 alkyl.

23. The compound of claim 1 wherein R 8 is C 1-10 alkyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl, each optionally substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from halo, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 , haloalkyl, C 1-4 hydroxyalkyl, C 1-4 cyanoalkyl, Cy′, —(C 1-4 alkyl)-Cy′, CN, NO 2 , —(CH 2 ) q —OR a′ , —(CH 2 ) q —SR a′ , —(CH 2 ) q —C(O)R b′ , —(CH 2 ) q —C(O)NR c′ R d′ , —(CH 2 ) q —C(O)OR a′ , —(CH 2 ) q —OC(O)R b′ , —(CH 2 ) q OC(O)NR c′ R d′ , —(CH 2 ) q —NR c′ R d′ , —(CH 2 ) q NR C′ C(O)R b′ , —(CH 2 ) q NR C′ C(O)NR C′ R d , —(CH 2 ) q —NR c′ C(O)OR a′ , —(CH 2 ) q S(O)R b′ , —(CH 2 ) q —S(O)NR C′ R d′ , —(CH 2 ) q S(O)R b′ , —(CH 2 ) q NR c′ S(O) 2 R b , and —(CH 2 ) q —S(O) 2 NR c′ R d′ .

24. The compound of claim 1 wherein R 8 is C 1-10 alkyl optionally substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from halo, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, C 4 cyanoalkyl, Cy′, —(C 1-4 alkyl)-Cy′, CN, NO 2 , —(CH 2 ) q —OR 2 , (CH 2 ) q )SR a′ , —(CH 2 ) q —C(O)R b′ , —(CH 2 ) q —C(O)NR c′ R b′ , —(CH 2 ) q —C(O)OR a′ , —(CH 2 ) q —OC(O)R b′ , —(CH 2 ) q —OC(O)NR c′ R d′ , —(CH 2 ) q —NR C″ R d′ , —(CH 2 ) q —NR c′ C(O)R b′ , —(CH 2 ) q —NR c′ C(O)NR c′ R d′ , —(CH 2 ) q —NRC C′ (O)OR a′ , —(CH 2 ) q —S(O)R b′ , —(CH 2 ) q —S(O)NR c′ R d′ , —(CH 2 ) q —S(O) 2 R b′ , —(CH 2 ) q —NR c′ S(O) 2 R b′ , and —(CH 2 ) q —S(O) 2 NR c′ R d′ .

25. The compound of claim 1 wherein R 8 is aryl or heteroaryl, each optionally substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from halo, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, C 1-4 cyanoalkyl, Cy′, —(C 1-4 alkyl)-Cy′, CN, NO 2 , —(CH 2 ) q —OR a , —(CH 2 ) q SR a′ , —(CH 2 ) q —C(O)R b′ , —(CH 2 ) q —C(O)NR C′ R d′ , —(CH 2 ) q —C(O)OR a′ , —(CH 2 ) q —OC(O)R b′ , —(CH 2 ) q —OC(O)NR c′ R d′ , —(CH 2 ) q —NR c′ R d′ , —(CH 2 ) q —NR c′ C(O)R b′ , —(CH 2 ) q q-NR c′ C(O)NR c′ R d′ , —(CH 2 ) q —NR C′ C(O)OR a′ , —CH 2 ) q —S(O)R b′ , —(CH 2 ) q —S(O)NR c′ R d′ , —(CH 2 ) q —S(O) 2 R b′ , —(CH 2 ) q —NR c′ S(O) 2 R b′ , and (—(CH 2 ) q —S(O) 2 NR C′ R d′ .

26. The compound of claim 1 wherein R 8 is cycloalkyl or heterocycloalkyl, each optionally substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from halo, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, C 1-4 cyanoalkyl, Cy′, —(C 1-4 alkyl)-Cy′, CN, NO 2 , —(CH 2 ) q —OR a′ , —(CH 2 ) q —SR a′ , —(CH 2 ) q —C(O)R b′ , —(CH 2 ) q —C(O)NR c′ R d′ , —(CH 2 ) q —C(O)OR a′ , —(CH 2 ) q —OC(O)R b′ , —(CH 2 ) q —OC(O)NR c′ R′, —(CH 2 ) q —NR c′ R d′ , —(CH 2 ) q —NR c′ C(O)R b′ , —(CH 2 ) q —NR c′ C(O)NR c′ R d′ , —(CH 2 ) q —NR c′ C(O)OR a′ , —(CH 2 ) q —S(O)R b′ , —(CH 2 ) q —S(O)NR c′ R d′ , —(CH 2 ) q —S(O) 2 R b′ , —(CH 2 ) q —NR c′ S(O) 2 R b′ , and —(CH 2 ) q —(O) 2 NR c′ R d′ .

27. The compound of claim 1 wherein R 8 is phenyl optionally substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from halo, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, C 1-4 cyanoalkyl, Cy′, —(C 1-4 alkyl)-Cy′, CN, NO 2 , —(CH 2 ) q —OR a′ , —(CH 2 ) q —SR a′ , —(CH 2 ) q —C(O)R b′ , —(CH 2 ) q —C(O)NR c′ R d′ , —(CH 2 ) q —C(O)OR a′ , —(CH 2 ) q —OC(O)R b′ , —(CH 2 ) q —C(O)NR c′ R′, —(CH 2 ) q —NR c′ R d′ , —(CH 2 ) q NR c′ C(O)R b′ , —(CH 2 ) q —NR c′ C(O)NR c′ R d′ , —(CH 2 ) q —NR c′ C(O)OR a′ , —(CH 2 ) q —S(O)R b′ , —(CH 2 ) q —S(O)NR c′ R d′ , —(CH 2 ) q —S(O) 2 R b′ , —(CH 2 ) q —NR c′ S(O) 2 R b′ , and —(CH 2 ) q —S(O) 2 NR c′ R d′ .

28. The compound of claim 1 wherein n is 0 and R 8 is C 1-8 alkyl, substituted with 1, 2, or 3 substituents independently selected from OH, halo, and —(CH 2 ) q —C(O)R b′ .

29. The compound of claim 1 wherein n is 1, L is C 1-4 alkylenyl, and R 8 is aryl or heteroaryl each optionally substituted with 1, 2, or 3 substituents selected from halo, C 1-4 alkyl, C 1-4 haloalkyl, OR a′ , and —(CH 2 ) q —C(O)R b′ .

30. The compound of claim 1 wherein L is C 1-4 alkylenyl.

31. The compound of claim 1 wherein L is methylene.

32. The compound of claim 1 wherein L is C(O) or S(O) 2 .

33. The compound of claim 1 having Formula Ia:

34. The compound of claim 1 having Formula Ib, Ic or Id:

35. The compound of claim 1 having Formula Ie of If:

36. The compound of claim 1 having the Formula Ig:

37. The compound of claim 1 selected from

4-{[(1R3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]amino}-1-(5-pyrimidin-2-yl pyridin-2-yl)cyclohexanol;

ethyl 4-{[(1R3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]amino}-3-methoxypiperidine-1-carboxylate;

methyl 4-{[1R3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]amino}-3-methoxypiperidine-1-carboxylate;

((1S,3R)-3-(3-oxa-bicyclo [3.3.1]nonan-9-ylamino)-1-isopropylcyclopentyl)(4-(4(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone;

(1R,3S)-N-[(5-chloro-2-thienyl)methyl]-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentanamine; (1R,3S)-3-isopropyl-N-[(1-pyridin-3-yl-1H-pyrrol-2-yl)methyl]-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}carbonyl)cyclopentanamine;

(1R,3S)-N-[(1-ethyl-1H-pyrazol-4-yl)methyl]-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2yl]piperazin-1-yl}carbonyl)cyclopentanamine; (1R,3S)-3-isopropyl-N-(quinolin-6-ylmethyl)-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentanamine;

7-({[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]amino}methyl)-1H-pyrido[23-b][14]oxazin-2(3H)-one;

(1R,3S)-N-(24-dimethoxybenzyl)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentanamine;

N-[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}carbonyl)cyclopentyl]-1pyrimidin-2-ylpiperidin-3-amine;

1-but-2-yn-1-yl-5-{[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]amino}azepan-2-one;

N-isopropyl-3-(2-{[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]amino}cyclopentyl)propanamide;

N-[(1R3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]indan-2-amine;

N-[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]tetrahydro-2H-thiopyran-4-amine 11-dioxide;

(1R,3S)-N-cyclopentyl-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentanamine;

3-(2-{[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]amino}cyclopentyl)-N-propylpropanamide;

6,8-difluoro-N-[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]-1234-tetrahydronaphthalen-2-amine;

N-[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}carbonyl)cyclopentyl]1234-tetrahydronaphthalen-2-amine;

2,5-anhydro-1,3,4-trideoxy-3-{[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]amino}pentitol;

N-[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}carbonyl)cyclopentyl]-35-dimethyltetrahydro-2H-pyran-4-amine;

(1R,3S)-3-isopropyl-N-[1-methyl-3-(1H-pyrazol-1-yl)propyl]-3-({4-[4-(trifluoromethyl)pyridin-2yl]piperazin-1yl}carbonyl)cyclopentanamine;

N-[(1R,3S)-3-isopropyl-3-({-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]tetrahydrofuran-3-amine;

N-[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}carbonyl)cyclopentyl]-Nmethyltetrahyclrofuran-3-amine;

(1R,3S)-N-(34-dimethoxybenzyl)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentanamine;

(1R,3S)-N-(1H-indol-5-ylmethyl)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentanamine;

4-({[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]amino}methyl)phenol;

(1R,3S)-N-(4-fluorobenzyl)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentanamine;

5-({[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]amino}methyl)-2-methoxyphenol;

6-({[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1yl}carbonyl)cyclopentyl]amino}methyl)-2H-[4-benzoxazin-3(4H)-one;

(1R,3S)-3-isopropyl-N-(3′-methoxy-4-methylbenzyl)-3-({-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}carbonyl)cyclopentanamine;

((1S,3R)-3-(benzylamino)-1-isopropylcyclopentyl)(4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1yl)methanone;

((1S,3R)-3-(4-chlorobenzylamina)-1-isopropylcyclopentyl)(4-(4-(trifluoromethyl)pyridin-2yl) piperazin-1-yl)methanone;

((1S,3R)-3-(4-methoxybenzylamina)-1-isopropylcyclopentyl)(4-(4-(trifluoromethyl)pyridin-2yl) piperazin-1-yl)methanone;

((1S,3R)-3-(4-hydroxy-3-methylbutan-2-ylamina)-1-isopropylcyclopentyl)(4-(4(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone;

((1S,3R)-3-(4-hydroxy-4-methylpentan-2-ylamino)-1-isopropylcyclopentyl)(4-(4(trifluoromethyl)pyridin-2-yl)-5,6-dihydropyridin-1(2H)-yl)methanone;

((1S,3R)-3-(2-(chloromethyl)-3-hydroxy-2-methyl propylamino)-1-isopropylcyclopentyl)(4-(4(trifluoromethyl)pyridin-2-yl)-5,6-dihydropyridin-1(2H)-yl)methanone;

((1S,3R)-1-isopropyl-3-((tetrahydro-2H-pyran-4-yl)methylamino)cyclopentyl)(4(4(trifluoromethyl)pyridin-2-yl)-5,6-dihydropyridin-1(2H)-yl)methanone;

((1S,3R)-1-isopropyl-3-(methyl(neopentyl)amina)cyclopentyl)(4-(4-(trifluoromethyl)pyridin-2yl)piperazin-1-yl)methanone;

N-((1R,3S)-3-isopropyl-3-(1-(4-(trifluoromethyl)pyridin-2-yl)piperazine-4carbonyl)cyclopentyl)benzenesulfonamide;

((1S,3R)-1-isopropyl-3-(1-phenylethylamino)cyclopentyl)(4-(4-(trifluoromethyl)pyridin-2yl)piperazin-1-yl)methanone;

((1S,3R)-1-isopropyl-3-(1-phenylpropylamino)cyclopentyl(4-(4-(trifluoromethyl)pyridin-2yl) piperazin-1-yl)methanone;

((1S,3R)-3-(diethylamina)-1-isopropylcyclopentyl)(4-(5-(trifluoromethyl)pyridin-3-yl)-5,6dihydropyridin-1(2H)-yl)methanone;

((1S,3R)-1-isopropyl-3-(1-(tetrahydro-2H-pyran-4-yl)ethylamino)cyclopentyl)(4-(4(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)methanone;

((1S,3R)-1-isopropyl-3-((3-methoxy-tetrahydro-2H-pyran-4-yl)methylamina)cyclopentyl)(4-(6(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone;

((1S,3R)-3-(1,2-diphenylethylamino)-1-isopropylcyclopentyl)(4-(6-(trifluoromethyl)pyrimidin-4yl)piperazin-1-yl)methanone;

((1S,3R)-1-isopropyl-3-(phenethylamino)cyclopentyl)(4-(2-methyl-6-(trifluoromethyl)pyrimidin-4yl)piperazin-1-yl)methanone;

3-fluoro-N-((1R,3S)-3-isopropyl-3-(1(4-(trifluoromethyl)pyridin-2-yl)piperazine-4carbonyl)cyclopentyl)benzenesulfonamide; 3-((1R,3S)-3-(2-hydroxypropan-2-yl)-3-(1-(4(trifluoromethyl)pyridin-2-yl)piperazine-4-carbonyl)cyclopentylamino)-2,2-dimethylpropanoic acid;

((1S,3R)-1-isopropyl-3-(pyridin-3-ylmethylamina)cyclopentyl)(4-(4-(trifluoromethyl)pyridin-2yl)piperazin-1-yl)methanone;

((1S,3R)-3-(3-hydroxypropylamino)-1-isopropylcyclopentyl)(4-(4-(trifluoromethyl)pyridin-2yl)piperazin-1-yl)methanone;

((1S,3R)-3-(benzyl(isopropyl)amino)-1-isopropylcyclopentyl)(4-(4-(trifluoromethyl)pyridin-2yl)piperazin-1-yl)methanone;

N-((1R,3S)-3-isopropyl-3-(1-(4-(trifluoromethyl)pyridin-2-yl)piperazine-4carbonyl)cyclopentyl)benzamide;

N-((1R,3S)-3-isopropyl-3-(1-(4-(trifluoromethyl)pyridin-2-yl)piperazine-4carbonyl)cyclopentyl)cyclohexanecarboxamide;

N-((1R,3S)-3-isopropyl-3-(1-(4-(trifluoromethyl)pyridin-2-yl)piperazine-4-carbonyl)cyclopentyl)-2(tetrahydro-2H-pyran-4-yl)acetamide;

((1S,3R)-1-isopropyl-3-{naphthalen-2-ylmethylamina}cyclopentyl)(4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone;

((1S,3R)-3-(4-hydroxy-4-(thiazol-2-yl)cyclohexylamino)-1-isopropylcyclopentyl)(4-(4(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone;

((1S,3R)-3-(4-phenoxybenzylamino)-1-isopropylcyclopentyl)(4-(4-(trifluoromethyl)pyridin-2yl)piperazin-1-yl)methanone;

((1S,3R)-3-(3,4-dimethoxybenzylamino)-1-isopropylcyclopentyl)(4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone;

((1S,3R)-3-(3,5-bis(trifluoromethyl)benzylamina)-1-isopropylcyclopentyl)(4-(4(trifluoromethyl) pyridin-2-yl)piperazin-1-yl)methanone;

N-((1R,3S)-3-isopropyl-3-(1-(4-(trifluoromethyl)pyridin-2-yl)piperazine-4carbonyl)cyclopentyl)methanesulfonamide;

N-((1R,3S)-3-isopropyl-3-(1-(4-(trifluoromethyl)pyridin-2-yl)piperazine-4-carbonyl)cyclopentyl)-4(trifluoromethyl)benzenesulfonamide; or

((1S,3R)-1-isopropyl-3-(neopentylamino)cyclopentyl)(4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1yl)methanone.

38. A composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.