Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation
View Patent ↗This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.
1. A method for forming a terminal oligomer block and a condensing oligomer block from a bifunctional single set library, said method comprising:
(a) providing a bifunctional single set library comprising at least two oligomer blocks;
(b) treating an oligomer block of the bifunctional single set library to thereby remove one or more protecting groups and produce a terminal oligomer block; and
(c) treating an oligomer block of the bifunctional single set library to remove different one or more protecting groups as compared with step (b) and thereby produce a condensing oligomer block.
2. The method of claim 1 further comprising condensing the terminal oligomer block and the condensing oligomer block.
3. The method of claim 2 , wherein condensation of the terminal oligomer block with the condensing oligomer block produces a combination oligomer comprising a linker of at least three atoms in length.
4. The method of claim 1 , wherein the oligomer blocks of the bifunctional single set library are peptide nucleic acid oligomer, PNA chimera or PNA combination oligomer.