Methods of collagen imaging

1. A diagnostic composition comprising a compound having the following formula, or a pharmaceutically acceptable salt thereof:

[EMTG] n -[L] m -[C] p

wherein m and p are independently one to ten;

wherein n is one to five;

wherein C is a physiologically compatible metal chelating group;

wherein L is a linker; and

wherein EMTG is an Extracellular Matrix Targeting Group, wherein said EMTG comprises a cyclic peptide comprising an amino acid sequence selected from:

(SEQ. ID NO. 828)

W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G;

(SEQ. ID NO. 829)

G-W-H-C-Y-T-Y-F-P-H-H-Y-C-T-Y-G;

(SEQ. ID NO. 830)

A-W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G;

(SEQ. ID NO. 831)

L-W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G; and

(SEQ. ID NO. 832)

Y-W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G,

wherein the C-terminus of the peptide may be amidated or any of the amino acids may be protected, and wherein the peptide has a length of 16 to 30 amino acids.

2. A diagnostic composition comprising a compound having the following formula, or a pharmaceutically acceptable salt thereof:

[EMTG] n -[L] m -[C] p

wherein m and p are independently one to ten;

wherein n is one to five;

wherein C is a physiologically compatible metal chelating group;

wherein L is a linker; and

wherein EMTG is an Extracellular Matrix Targeting Group, wherein said EMTG comprises a cyclic peptide comprising an amino acid sequence selected from:

C-T-T-S-F-P-H-H-Y-C,

(SEQ ID NO: 817)

C-T-T-K-F-P-H-H-Y-C,

(SEQ ID NO: 818)

C-Y-T-Y-F-P-H-H-Y-C,

(SEQ ID NO: 819)

C-T-T-R-F-P-H-H-Y-C,or

(SEQ ID NO: 820)

C-S-G-D-E-Y-T-W-H-C.

(SEQ ID NO: 821)

wherein the C-terminus of the peptide may be amidated or any of the amino acids may be protected, and wherein the peptide has a length of 10 to 30 amino acids.

3. A diagnostic composition comprising a compound having the structure of Compound ID 800

or a pharmaceutically acceptable salt thereof.

4. A diagnostic composition comprising a compound having the structure of Compound ID 801

or a pharmaceutically acceptable salt thereof.

5. A diagnostic composition comprising a compound having the structure of Compound ID 802

or a pharmaceutically acceptable salt thereof.

6. A diagnostic composition comprising a compound having the structure of Compound ID 803

or a pharmaceutically acceptable salt thereof.

7. A diagnostic composition comprising a compound having the structure of Compound ID 807

or a pharmaceutically acceptable salt thereof.

8. A diagnostic composition comprising a compound having the structure of Compound ID 808

or a pharmaceutically acceptable salt thereof.

9. A diagnostic composition comprising a compound having the structure of Compound ID 816

or a pharmaceutically acceptable salt thereof.

10. A diagnostic composition comprising a compound having the structure of Compound ID 813

or a pharmaceutically acceptable salt thereof.

11. A diagnostic composition comprising a compound having the structure of Compound ID 815

or a pharmaceutically acceptable salt thereof.

12. A diagnostic composition comprising a compound having the structure of Compound ID 1004

or a pharmaceutically acceptable salt thereof.

13. A diagnostic composition comprising a compound having the structure of Compound ID 1013

or a pharmaceutically acceptable salt thereof.

14. A diagnostic composition comprising the amino acid sequence:

W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G (SEQ. ID NO. 828);

G-W-H-C-Y-T-Y-F-P-H-H-Y-C-T-Y-G (SEQ. ID NO. 829);

A-W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G (SEQ. ID NO. 830);

L-W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G (SEQ. ID NO. 831); or

Y-W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G (SEQ. ID NO. 832), or a pharmaceutically acceptable salt thereof.

15. A diagnostic composition comprising a compound having the structure of Compound ID No. 1014

or a pharmaceutically acceptable salt thereof.

16. The diagnostic composition of claim 15 , further comprising a pharmaceutically acceptable ingredient, excipient, carrier, adjuvant, or vehicle.

17. The diagnostic composition of claim 1 , 2 , 3 - 11 , 12 , 13 , or 14 , further comprising a pharmaceutically acceptable ingredient, excipient, carrier, adjuvant, or vehicle.