STEREOISOMERS OF FATTY ACID ANALOGS FOR DIAGNOSTIC IMAGING
The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a fatty acid analog. The invention also provides methods for using the novel imaging agents, and kits containing one or more of the novel imaging agents of the invention.
1 . A method of imaging cardiovascular tissue in a mammal comprising:
(a) administering to a mammal an imaging agent comprising a radionuclide in spatial proximity to an isomer of a fatty acid analog that includes a cyclic moiety;
(b) detecting the spatial distribution of the imaging agent in the mammal.
2 . The method of claim 1 in which the cyclic moiety is a phenyl ring and the isomer is a stereoisomer.
3 . The method of claim 1 in which the cyclic moiety is an aliphatic ring and the isomer is a cis or trans isomer.
4 . The method of claim 3 in which the cyclic moiety is a cyclopropyl ring.
5 . The method of claim 3 in which the cyclic moiety is a cyclobutyl ring.
6 . The method of claim 3 in which the cyclic moiety is an oxiranyl ring.
7 . The method of claim 3 in which the cyclic moiety is an thioranyl ring.
8 . The method of claim 3 in which the cyclic moiety is an aziridinyl ring.
9 . The method of claim 1 in which the cyclic moiety is integral to the fatty acid chain.
10 . The method of claim 1 in which the cyclic moiety is pendent from the fatty acid chain.
11 . The method of claim 1 in which the radionuclide is 11 C, 18 F, 62 Cu, 68 Ga, 99m Tc, 111 In, 123 I, or 131 I.