6-aminoisoquinoline compounds
View Patent ↗6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
1. A compound according to Formula (I):
wherein A is —OCH 2 , —CH 2 S—, —SCH 2 , —CH 2 CH 2 —, —CH(R 10 )CH 2 , —CH 2 CH(R 10 ), —CH═CH—,
wherein R 10 is hydrogen, unsubstituted C 1 -C 4 alkyl, C 1 -C 4 alkenyl, C 1 -C 4 alkynyl, or amino;
wherein R 1 , and R 2 are hydrogen; and
wherein R 3 is hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, amino, cyano, cycloalkyl, heterocycloalkyl, aryl, C 1 -C 4 alkyl aryl, heteroaryl, C 1 -C 4 alkyl heteroaryl, carbonyl, carbonylamino, thioalkyl, sulfonyl, sulfonylamino, acyl, or carboxyl.
2. A compound according to claim 1 , wherein the compound is selected from the following:
3. A compound according to claim 1 , wherein A is —OCH 2 , —CH 2 S—, —SCH 2 , —CH 2 CH 2 —, —CH(R 10 )CH 2 , —CH 2 CH(R 10 ), —CH═CH—, or , wherein R 10 is amino;
wherein R 1 , and R 2 are hydrogen; and
wherein R 3 is hydrogen, amino, cycloalkyl, aryl, C 1 -C 4 alkyl aryl, heteroaryl, or C 1 -C 4 alkyl heteroaryl.