Mixed amino acid/mineral compounds having improved solubility
View Patent ↗Mixed amino acid/mineral compounds can include at least two amino acids bound to a central mineral atom. The combination of amino acids can be tailored to provide improved solubility, absorption, and/or bioavailability of the mineral. Optionally, organic acids can be bound to the mineral or combined with the chelate in order to further improve solubility, absorption, and/or bioavailability. Compositions including one or more mixed amino acid/mineral compounds can be included in therapeutic regimens for indications in which the mineral may treat and/or prevent a condition or symptom.
1. A composition comprising:
a metal chelate consisting essentially of:
a iron(II);
a glycine chelated to the iron(II); and
an aspartic acid chelated to the iron(II), wherein the metal chelate has a solubility from about 2.25 M to about 5 M;
a malic acid or salt thereof in an amount of from about 7% to about 8% by weight of the composition to improve solubility of the metal chelate in water;
a succinic acid or salt thereof in an amount of from about 7% to about 10% by weight of the composition to improve intestinal absorption of the metal chelate; and
with the metal chelate in an amount of from about 77% to about 84.5% by weight of the composition.
2. A composition as in claim 1 , wherein the composition comprises:
succinic acid or salt thereof in an amount of about 10% by weight of the composition;
malic acid or salt thereof in an amount of about 7% by weight of the composition; and
the chelate in an amount of about 77% by weight of the composition.
3. A composition as in claim 1 , wherein the composition comprises:
succinic acid or salt thereof in an amount of about 8% by weight of the composition;
malic acid or salt thereof in an amount of about 7% by weight of the composition; and
the chelate in an amount of about 84% by weight of the composition.
4. A composition as in claim 1 , wherein the composition comprises:
succinic acid or salt thereof in an amount of about 7% by weight of the composition;
malic acid or salt thereof in an amount of about 8% by weight of the composition;
glycine in an amount of about 48% by weight of the composition;
aspartic acid in an amount of about 15% by weight of the composition; and
the iron atom in an amount of about 21% by weight of the composition.
5. A composition as in claim 1 , wherein the composition comprises:
fumed silica in an amount of about 0.5% by weight of the composition;
succinic acid or salt thereof in an amount of about 7% by weight of the composition;
malic acid or salt thereof in an amount of about 8% by weight of the composition;
glycine in an amount of about 48% by weight of the composition;
aspartic acid in an amount of about 15% by weight of the composition; and
the iron atom in an amount of about 21% by weight of the composition.
6. A chelate as in claim 1 , wherein the chelate has a solubility of about 2.5 M.