Laser based metal deposition (LBMD) of antimicrobials to implant surfaces
View Patent ↗A method is provided for depositing a hard wear resistant surface onto a porous or non-porous base material of a medical implant. The wear resistant surface of the medical implant device may be formed by a Laser Based Metal Deposition (LBMD) method such as Laser Engineered Net Shaping (LENS). The wear resistant surface may include a blend of multiple different biocompatible materials. Further, functionally graded layers of biocompatible materials may be used to form the wear resistant surface. Usage of a porous material for the base may promote bone ingrowth to allow the implant to fuse strongly with the bone of a host patient. The hard wear resistant surface provides device longevity, particularly when applied to bearing surfaces such as artificial joint bearing surfaces or a dental implant bearing surfaces. An antimicrobial material such as silver may be deposited in combination with a metal to form an antimicrobial surface deposit.
1. A method for constructing a biomedical implant, the method comprising:
forming a base structure from a metal material; and
depositing on the base structure a deposit in functionally graded layers, the deposit comprising an antimicrobial material and a first metal, wherein the outermost layers possess the most potent antimicrobial properties, wherein depositing the deposit is accomplished in an inert gas atmosphere.
2. A method as in claim 1 , wherein the antimicrobial material comprises at least one of elemental silver, gold, platinum, palladium, iridium, copper, tin, antimony, bismuth, zinc, salts thereof, or intermetallics thereof.
3. A method as in claim 1 , wherein the first metal comprises at least one of cobalt-chrome, tantalum, titanium, platinum, zirconium, niobium, stainless steel, or alloys thereof.
4. A method as in claim 1 , further comprising depositing the deposit with a thickness greater than 25 microns.
5. A method as in claim 1 , further comprising modifying the deposit by a process selected from the group consisting of annealing, etching in acid, etching in base, and oxygen plasma.
6. A method for constructing a biomedical implant, the method comprising:
forming a base structure from a metal material; and
depositing a deposit onto the metal base structure-by Laser Based Metal Deposition (LBMD) in an inert gas atmosphere, wherein the deposit comprises an antimicrobial material and a first metal, wherein depositing the deposit comprises functionally graded layers, wherein the outermost layers possess the most potent antimicrobial properties.
7. A method as in claim 6 , wherein the antimicrobial material comprises at least one of elemental silver, gold, platinum, palladium, iridium, copper, tin, antimony, bismuth, zinc, salts thereof, or intermetallics thereof.
8. A method as in claim 6 , wherein the first metal comprises at least one of cobalt-chrome, tantalum, titanium, platinum, zirconium, niobium, stainless steel, or alloys thereof.
9. A method as in claim 6 , wherein depositing the deposit further comprises selecting the metal base structure comprising a base shaped to be secured to a body part of a patient.
10. A method as in claim 6 , further comprising depositing the deposit with a thickness greater than 25 microns.
11. A method as in claim 6 , further comprising modifying the deposit by a process selected from the group consisting of annealing, etching in acid, etching in base, and oxygen plasma.
12. A method for constructing a biomedical implant, the method comprising:
forming a base structure from a biocompatible metal material;
selecting at least one selection from the group consisting of a first metal, an antimicrobial material, a porous bone ingrowth material, a bearing material, and combinations thereof; and
depositing at least one deposit comprising the selection onto the metal base structure by Laser Based Metal Deposition (LBMD) in an inert gas atmosphere and in functionally graded layers, wherein the outermost layers possess the most potent antimicrobial properties.
13. A method as in claim 12 , wherein the antimicrobial material comprises at least one of elemental silver, gold, platinum, palladium, iridium, copper, tin, antimony, bismuth, zinc, salts thereof, or intermetallics thereof.
14. A method as in claim 12 , wherein the first metal comprises at least one of cobalt-chrome, tantalum, titanium, platinum, zirconium, niobium, stainless steel, or alloys thereof.
15. A method as in claim 12 , wherein the first metal comprises at least one of cobalt-chrome, tantalum, titanium, platinum, zirconium, niobium, stainless steel, or alloys thereof.
16. A method as in claim 12 , further comprising selecting the bearing material of a biocompatible composition comprising cobalt and chromium.
17. A method as in claim 12 , wherein depositing at least one deposit further comprises selecting the metal base structure comprising a base shaped to be secured to a body part of a patient.
18. A method as in claim 12 , further comprising depositing each deposit with a thickness greater than 25 microns.
19. A method as in claim 12 , further comprising modifying the deposit by a process selected from the group consisting of annealing, etching in acid, etching in base, and oxygen plasma.
20. A method for constructing a biomedical implant, the method comprising:
forming a base structure from a biocompatible metal material; and
depositing on the base structure a deposit to provide a surface other than a bone apposition surface or an articular surface via Laser Based Metal Deposition (LBMD) in an inert gas atmosphere, wherein depositing the deposit to provide the surface comprises positioning the surface to contact a non-articulating non-bony tissue adjacent to the implant.
21. The method of claim 20 , wherein depositing the deposit comprises depositing an antimicrobial material.
22. The method of claim 21 , further comprising depositing at least one deposit in functionally graded layers wherein the outermost layers possess the most potent antimicrobial properties.
23. The method of claim 20 , wherein the antimicrobial material comprises at least one of elemental silver, gold, platinum, palladium, iridium, copper, tin, antimony, bismuth, zinc, salts thereof, or intermetallics thereof.
24. The method of claim 20 , wherein the first metal comprises at least one of cobalt-chrome, tantalum, titanium, platinum, zirconium, niobium, stainless steel, or alloys thereof.
25. The method of claim 20 , wherein depositing the deposit further comprises selecting the metal base structure comprising a base shaped to be secured to a body part of a patient.
26. The method of claim 20 , further comprising depositing at least one deposit in functionally graded layers.
27. A method for constructing a biomedical implant, the method comprising:
forming a base structure from a metal material; and
depositing on the base structure a deposit comprising an antimicrobial material and a first metal, wherein depositing the deposit is accomplished in an inert gas atmosphere, wherein the antimicrobial material comprises at least one of elemental silver, gold, platinum, palladium, iridium, copper, tin, antimony, bismuth, zinc, salts thereof, or intermetallics thereof.
28. A method as in claim 27 , wherein the first metal comprises at least one of cobalt-chrome, tantalum, titanium, platinum, zirconium, niobium, stainless steel, or alloys thereof.
29. A method as in claim 27 , further comprising depositing the deposit with a thickness greater than 25 microns and modifying the deposit by a process selected from the group consisting of annealing, etching in acid, etching in base, and oxygen plasma.
30. A method for constructing a biomedical implant, the method comprising:
forming a base structure from a metal material; and
depositing a deposit comprising an antimicrobial material and a first metal onto the metal base structure by Laser Based Metal Deposition (LBMD) in an inert gas atmosphere, wherein the antimicrobial material comprises at least one of elemental silver, gold, platinum, palladium, iridium, copper, tin, antimony, bismuth, zinc, salts thereof, or intermetallics thereof.
31. A method as in claim 30 , wherein the first metal comprises at least one of cobalt-chrome, tantalum, titanium, platinum, zirconium, niobium, stainless steel, or alloys thereof.
32. A method as in claim 30 , wherein depositing the deposit further comprises selecting the metal base structure comprising a base shaped to be secured to a body part of a patient.
33. A method as in claim 30 , further comprising depositing the deposit with a thickness greater than 25 microns and modifying the deposit by a process selected from the group consisting of annealing, etching in acid, etching in base, and oxygen plasma.
34. A method for constructing a biomedical implant, the method comprising:
forming a base structure from a metal material;
depositing a deposit comprising an antimicrobial material and a first metal onto the metal base structure by Laser Based Metal Deposition (LBMD) in an inert gas atmosphere; and
modifying the deposit by a process selected from the group consisting of annealing, etching in acid, etching in base, and oxygen plasma.
35. A method as in claim 34 , further comprising selecting the bearing material of a biocompatible composition comprising cobalt and chromium, and wherein the antimicrobial material comprises at least one of elemental silver, gold, platinum, palladium, iridium, copper, tin, antimony, bismuth, zinc, salts thereof, or intermetallics thereof, and wherein the first metal comprises at least one of cobalt-chrome, tantalum, titanium, platinum, zirconium, niobium, stainless steel, or alloys thereof.
36. A method as in claim 34 , wherein depositing at least one deposit further comprises selecting the metal base structure comprising a base shaped to be secured to a body part of a patient, wherein depositing each deposit with a thickness greater than 25 microns.
37. A method as in claim 34 , further comprising depositing the at least one deposit in functionally graded layers wherein the outermost layers possess the most potent antimicrobial properties.
38. A method for constructing a biomedical implant, the method comprising:
forming a base structure from a biocompatible metal material;
selecting at least one selection from the group consisting of a first metal, an antimicrobial material, a porous bone ingrowth material, a bearing material, and combinations thereof, wherein the antimicrobial material comprises at least one of elemental silver, gold, platinum, palladium, iridium, copper, tin, antimony, bismuth, zinc, salts thereof, or intermetallics thereof; and
depositing at least one deposit comprising the selection onto the metal base structure by Laser Based Metal Deposition (LBMD) in an inert gas atmosphere.
39. A method as in claim 38 , further comprising selecting the bearing material of a biocompatible composition comprising cobalt and chromium, and wherein the first metal comprises at least one of cobalt-chrome, tantalum, titanium, platinum, zirconium, niobium, stainless steel, and alloys thereof, and wherein the first metal comprises at least one of cobalt-chrome, tantalum, titanium, platinum, zirconium, niobium, stainless steel, or alloys thereof.
40. A method as in claim 38 , wherein depositing at least one deposit further comprises selecting the metal base structure comprising a base shaped to be secured to a body part of a patient, wherein depositing each deposit with a thickness greater than 25 microns and modifying the deposit by a process selected from the group consisting of annealing, etching in acid, etching in base, and oxygen plasma.
41. A method for constructing a biomedical implant, the method comprising:
forming a base structure from a biocompatible metal material;
selecting at least one selection from the group consisting of a first metal, an antimicrobial material, a porous bone ingrowth material, a bearing material, and combinations thereof;
depositing at least one deposit comprising the selection onto the metal base structure by Laser Based Metal Deposition (LBMD) in an inert gas atmosphere; and
modifying the deposit by a process selected from the group consisting of annealing, etching in acid, etching in base, and oxygen plasma.
42. A method as in claim 41 , further comprising selecting the bearing material of a biocompatible composition comprising cobalt and chromium, and wherein the antimicrobial material comprises at least one of elemental silver, gold, platinum, palladium, iridium, copper, tin, antimony, bismuth, zinc, salts thereof, or intermetallics thereof, and wherein the first metal comprises at least one of cobalt-chrome, tantalum, titanium, platinum, zirconium, niobium, stainless steel, or alloys thereof.
43. A method as in claim 41 , wherein depositing at least one deposit further comprises selecting the metal base structure comprising a base shaped to be secured to a body part of a patient, wherein depositing each deposit with a thickness greater than 25 microns.
44. A method as in claim 41 , further comprising depositing the at least one deposit in functionally graded layers wherein the outermost layers possess the most potent antimicrobial properties.
45. A method for constructing a biomedical implant, the method comprising:
forming a base structure from a biocompatible metal material; and
depositing on the base structure a deposit to provide a surface other than a bone apposition surface or an articular surface via Laser Based Metal Deposition (LBMD) in an inert gas atmosphere, wherein depositing the deposit comprises depositing an antimicrobial material in functionally graded layers wherein the outermost layers possess the most potent antimicrobial properties.
46. The biomedical implant of claim 45 , wherein depositing the deposit to provide the surface comprises positioning the surface to contact a non-articulating non-bony tissue adjacent to the implant.
47. The method of claim 45 , wherein the antimicrobial material comprises at least one of elemental silver, gold, platinum, palladium, iridium, copper, tin, antimony, bismuth, zinc, salts thereof, or intermetallics thereof, and wherein the first metal comprises at least one of cobalt-chrome, tantalum, titanium, platinum, zirconium, niobium, stainless steel, or alloys thereof.
48. The method of claim 45 , wherein depositing the deposit further comprises selecting the metal base structure comprising a base shaped to be secured to a body part of a patient.