IP Library › Granted Patent US 7,445,905
Granted Patent B2
US 7,445,905 · App. 11/627,492 · Granted Nov 4, 2008

Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders

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Quick Facts
Patent No.
US 7,445,905
App. No.
11/627,492
Granted
Nov 4, 2008
Kind
B2
Abstract

The present invention is directed to interleukin-22 polypeptides and nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Claims (6)

1. A method of detecting interleukin-22 (IL-22) polypeptide in a sample suspected of containing an IL-22 polypeptide, said method comprising contacting said sample with the interleukin-10 receptor Beta (IL-10R beta) polypeptide of SEQ ID NO:3 or the interleukin-22 receptor (IL-22R) polypeptide of SEQ ID NO: 4 and determining the formation of an IL-22/IL-10R beta polypeptide complex or an IL-22/IL-22R polypeptide complex in said sample, wherein the formation of a complex is indicative of the presence of IL-22 polypeptide in said sample.

2. The method according to claim 1 , wherein said sample comprises cells suspected of expressing said IL-22 polypeptide.

3. The method according to claim 1 , wherein said IL-22R polypeptide is labeled with a detectable label or is attached to a solid support.

4. A method of detecting interleukin-22 receptor (IL-22R) polypeptide in a sample suspected of containing an IL-22R polypeptide, said method comprising contacting said sample with the interleukin-22 (IL-22) polypeptide of SEQ ID NO: 2 and determining the formation of an IL-22R/IL-22 polypeptide complex in said sample, wherein the formation of a complex is indicative of the presence of IL-22R polypeptide in said sample.

5. The method according to claim 4 , wherein said sample comprises cells suspected of expressing said IL-22R polypeptide.

6. The method according to claim 4 , wherein said IL-22 polypeptide is labeled with a detectable label or is attached to a solid support.