IP Library › Granted Patent US 7,892,726
Granted Patent B2
US 7,892,726 · App. 11/628,648 · Granted Feb 22, 2011

Method for sterilizing lyophilized eukaryotic anuclear cells with gamma irradiation

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Quick Facts
Patent No.
US 7,892,726
App. No.
11/628,648
Granted
Feb 22, 2011
Kind
B2
Abstract

The invention provides a method for the sterilization of a biological preparation comprising desired viable biological entities. The method comprises irradiating a dried (e.g. freeze-dried) biological preparation with ionizing or UV radiation at an intensity and for a duration sufficient to reduce the amount or activity of living-matter contaminants in the biological preparation, the intensity and duration selected such that at least part of the desired biological entities in the sample remains viable. The method of the invention is particularly suitable for the reduction of the amount or activity of contaminants such as bacteria or viruses from biological preparations comprising red blood cells or platelets.

Claims (10)

1. A method for sterilizing a biological preparation comprising a viable eukaryotic anuclear cell, the method comprising:

providing a viable freeze-dried biological preparation comprising a polyphenol and the viable eukaryotic anuclear; and

irradiating the freeze-dried biological preparation with ionizing radiation at an intensity and for a duration sufficient to reduce the amount or activity of living-matter contaminants in the biological preparation, the intensity and duration selected such that at least part of the viable biological preparation in the freeze dried biological preparation remains viable.

2. The method of claim 1 , wherein the freeze-dried biological preparation comprises blood or portion thereof.

3. The method of claim 1 , wherein the eukaryotic nucleus free cell is selected from the group consisting of red blood cells (RBC) or platelets.

4. The method of claim 1 , wherein the living-matter contaminants are selected from the group consisting of bacteria and viruses.

5. The method of claim 1 , wherein the amount or activity of living-matter contaminants is reduced.

6. The method of claim 1 , wherein the ionizing radiation is gamma radiation.

7. The method of claim 6 , wherein the gamma radiation is below 2.5 mega Rad.

8. The method of claim 7 , wherein the gamma radiation is below 1 mega Rad.

Assignments (1)
ASSIGNMENT OF TRADEMARK AND PATENT SECURITY AGREEMENT Recorded Apr 8, 2015
From: MEDINVEST CAPITAL S.A.R.L.; MORGAN STANLEY BANK INTERNATIONAL LIMITED
To: SANDLEFORD PARK LIMITED, AS SECURITY AGENT
Reel/Frame 035387/0041 →