Rage fusion proteins
View Patent ↗Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin C H 2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
1. A Receptor for Advanced Glycation Endproducts (RAGE) fusion protein comprising the amino acid sequence as set forth in SEQ ID NO: 37, or a sequence at least 90% identical thereto.
2. The fusion protein of claim 1 , comprising the amino acid sequence as set forth in SEQ ID NO: 36 or a sequence at least 90% identical thereto.
3. The fusion protein of claim 1 , comprising the amino acid sequence of as set forth in SEQ ID NO: 35 or a sequence at least 90% identical thereto.
4. The fusion protein of claim 1 , comprising the amino acid sequence as set forth in SEQ ID NO: 37.
5. The fusion protein of claim 1 , comprising the amino acid sequence as set forth in SEQ ID NO: 36.
6. The fusion protein of claim 1 , comprising the amino acid sequence as set forth in SEQ ID NO: 35.
7. A composition comprising a therapeutically effective amount of a Receptor for Advanced Glycation Endproducts (RAGE) fusion protein in a pharmaceutical carrier, wherein the RAGE fusion protein comprises the amino acid sequence as set forth in SEQ ID NO: 37, or a sequence at least 90% identical thereto.
8. The composition of claim 7 , wherein the RAGE fusion protein is formulated as an injectable solution.
9. The composition of claim 7 , wherein the RAGE fusion protein is formulated as a sterile lyophilized powder.
10. The composition of claim 7 , comprising the amino acid sequence as set forth in SEQ ID NO: 36 or a sequence at least 90% identical thereto.
11. The composition of claim 7 , comprising the amino acid sequence as set forth in SEQ ID NO: 35 or a sequence at least 90% identical thereto.
12. The composition of claim 7 , comprising the amino acid sequence as set forth in SEQ ID NO: 37.
13. The composition of claim 7 , comprising the amino acid sequence as set forth in SEQ ID NO: 36.
14. The composition of claim 7 , comprising the amino acid sequence as set forth in SEQ ID NO: 35.