Oedema detection
View Patent ↗A method of detecting tissue oedema in a subject. The method includes determining a measured impedance for first and second body segments. An index indicative of a ratio of the extra-cellular to intra-cellular fluid is then calculated for each body segment, with these being used to determine an index ratio based on the index for the first and second body segments. The index ratio can in turn be used to determine the presence, absence or degree of tissue oedema, for example by comparing the index ratio to a reference or previously determined index ratios.
1. A method of detecting tissue oedema in a subject, the method comprising:
a) determining a measured impedance for a first body segment;
b) determining a measured impedance for a second body segment, the second body segment being different from the first body segment;
c) for each body segment, and using the respective measured impedance, determining, using a processor of a processing system, an index indicative of a ratio of the extra-cellular to intra-cellular fluid;
d) determining, using the processor of the processing system, an index ratio based on the index for the first and second body segments; and
e) determining the presence, absence or degree of tissue oedema based on the index ratio.
2. A method according to claim 1 , wherein the method includes, in the processing system:
a) comparing the index ratio to at least one reference; and
b) determining the presence, absence or degree of tissue oedema based on the results of the comparison.
3. A method according to claim 2 , wherein the reference includes at least one of:
a) a predetermined threshold;
b) a tolerance determined from a normal population; and
c) a predetermined range.
4. A method according to claim 2 , wherein the reference includes an index ratio previously determined for the subject.
5. A method according to claim 4 , wherein the previously determined index ratio is determined prior to the subject undergoing at least one of:
a) surgery; and
b) treatment.
6. A method according to claim 1 , wherein the first and second body segments are different types of body segments.
7. A method according to claim 1 , wherein the first and second body segments are limbs.
8. A method according to claim 1 , wherein the first body segment is a leg and the second body segment is an arm.
9. A method according to claim 1 , wherein the method includes, in the processing system:
a) determining a plurality of measured impedances for each body segment, each measured impedance being measured at a corresponding measurement frequency; and,
b) determining the index ratio based on the plurality of measured impedances.
10. A method according to claim 9 , wherein the method includes, in the processing system:
a) determining values for parameters R 0 and R ∞ from the measured impedance values; and,
b) calculating the index (I) using the equation:
I
=
R
∞
R
0
-
R
∞
where: R 0 is the resistance at zero frequency;
and, R ∞ is the resistance at infinite frequency.
11. A method according to claim 10 , wherein the method includes, in the processing system, determining the parameter values using the equation:
Z
=
R
∞
+
R
0
-
R
∞
1
+
(
j
ω
τ
)
(
1
-
α
)
where:
Z is the measured impedance at angular frequency ω,
τ is a time constant,
and α has a value between 0 and 1.
12. A method according to claim 11 , wherein the method includes, in the processing system:
a) determining the impedance of each body segment at four discrete frequencies; and,
b) determining values for the parameters by solving the equation using four simultaneous equations.
13. A method according to claim 10 , wherein the method includes, in the processing system, determining the parameter values by:
a) determining an impedance locus using the measured impedance values; and
b) using the impedance locus to determine the parameter values.
14. A method according to claim 1 , wherein the method includes, in the processing system, displaying an indication of at least one of:
a) the parameter values;
b) the ratio of extra-cellular to intra-cellular fluid; and,
c) an indication of the at least one of the presence, absence or degree of tissue oedema in the subject.
15. A method according to claim 1 , wherein the processing system is coupled to an apparatus comprising:
a) a current supply for generating an alternating current at each of a plurality of frequencies;
b) at least two supply electrodes for applying the generated alternating current to a subject;
c) at least two measurement electrodes for detecting a voltage across the subject; and,
d) a sensor coupled to the measurement electrodes for determining the voltage, the sensor being coupled to the processing system to thereby allow the processing system to determine the measured impedances.