Application of L-n-butylphthalide in preventing and treating dementia
View Patent ↗The invention discloses the application of l-n-butylphthalide as formula (I) in preparing a medicine for preventing and treating dementia, in special Alzheimer's disease and vascular dementia.
1. A method for treating dementia, comprising administering a therapeutically effective amount of the isolated optical isomer of L-n-butylphthalide represented in formula (I) to a patient
thereby treating dementia.
2. The method according to claim 1 , wherein the dementia is treated in a patient having Alzheimer's disease.
3. The method according to claim 1 , wherein the dementia is vascular dementia.
4. The method according to claim 1 , wherein the therapeutically effective amount is in the range of 0.1-100 mg/kg/day.
5. The method according to claim 1 , wherein the isolated optical isomer of L-n-butylphthalide is present in a pharmaceutical composition substantially free of D-n-butylphthalide.
6. The method according to claim 5 , wherein the pharmaceutical composition is in the form of tablets, capsules, pills, injections, sustained release formulation, controlled-release formulation or various microparticular delivery systems.