IP Library › Granted Patent US 8,163,296
Granted Patent B2
US 8,163,296 · App. 11/630,545 · Granted Apr 24, 2012

Dimensional analysis of saccharide conjugates with GPC and SEC-MALS

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Quick Facts
Patent No.
US 8,163,296
App. No.
11/630,545
Granted
Apr 24, 2012
Kind
B2
Abstract

GPC (gel permeation chromatography) and size exclusion chromatography with detection by multi-angle light scattering photometry (SEC-MALS) can be used to accurately measure molecular size and molar mass, respectively, of saccharide conjugates. The invention provides (a) a process for measuring the molecular size of a conjugated saccharide antigen within a sample, comprising a step of analyzing the sample by GPC, and (b) a process for measuring the molar mass of a conjugated saccharide antigen within a sample, comprising a step of analysing the sample by SEC-MALS.

Claims (2)

1. A composition comprising a conjugate of a capsular saccharide from serogroup A Neisseria meningitidis , wherein the molecular size of the conjugate is 57.1±2% Å and/or the molar mass of the conjugate is 88.5±2% kDa.

2. A composition comprising two or more of the conjugates as defined in claim 1 .

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 8, 2016
From: NOVARTIS VACCINES AND DIAGNOSTICS SRL
To: GLAXOSMITHKLINE BIOLOGICALS SA
Reel/Frame 040254/0677 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 1, 2008
From: NOVARTIS VACCINES AND DIAGNOSTICS SRL
To: NOVARTIS AG
Reel/Frame 021615/0451 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 25, 2008
From: CAPANNOLI, GIORGIO; CARINCI, VALERIA; D'ASCENZI, SANDRO; MAGAGNOLI, CLAUDIA
To: NOVARTIS VACCINES AND DIAGNOSTICS SRL
Reel/Frame 020418/0131 →