IP Library Granted Patent US 7,916,918
Granted Patent B2
US 7,916,918 · App. 11/632,082 · Granted Mar 29, 2011

Diagnostic system for multimodality mammography

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Quick Facts
Patent No.
US 7,916,918
App. No.
11/632,082
Granted
Mar 29, 2011
Kind
B2
Abstract

A method includes acquiring first imaging information of a region of interest, said first imaging information providing data correlated to three spatial dimensions of a reference frame including said region of interest; acquiring second projection imaging information of said region of interest, said second imaging information providing data correlated to said reference frame but is lacking information concerning at least one spatial dimension; and processing said first and second imaging information such that said first imaging information is registered with said second imaging information. An apparatus includes a first imaging system for acquiring imaging information of a region of interest, said first imaging information providing data correlated to three spatial dimensions of a reference frame including said region of interest; a second imaging system for acquiring second imaging information of said region of interest, said second imaging information providing data correlated to said reference frame but is lacking information concerning at least one spatial dimension; and a processor for processing said first and second imaging information such that said first imaging information is registered with said second imaging information.

Claims (33)

1. A method for use in medical imaging, comprising the steps of:

acquiring first volumetric imaging information of a region of interest, said first imaging information providing data that is correlated to three spatial dimensions of a reference frame including said region of interest;

acquiring second projection imaging information of said region of interest, said second imaging information providing data that is correlated to said reference frame but is lacking information concerning at least one of said spatial dimensions; and

processing said first imaging information and said second imaging information such that said first imaging information is registered with said second imaging information with respect to said three spatial dimensions of said reference frame.

2. A method as set forth in claim 1 , wherein said first imaging information is generated using a first imaging modality and said second imaging information is generated using a second imaging modality different than said first imaging modality.

3. A method as set forth in claim 2 , wherein said first imaging modality is one of ultrasound (US), magnetic resonance imaging (MRI) or computed tomography (CT).

4. A method as set forth in claim 2 , wherein said second imaging modality is a projection technology involving transmission of a signal relative to region of interest and detecting the signal at a detection surface so as to obtain said projection imaging information.

5. A method as set forth in claim 4 , wherein said first imaging modality is ultrasound (US) and said second imaging information is lacking information regarding a location of a feature of said location of interest relative to a transmission axis of said signal.

6. A method as set forth in claim 2 , wherein said second imaging modality is X-ray.

7. A method as set forth in claim 6 , wherein said region of interest is within a patient's breast.

8. A method as set forth in claim 1 , wherein said first imaging information and said second imaging information are obtained by a multi-modal system the first imaging information and the second imaging information have a positional relationship that is known with respect to at least one of said three-dimensions.

9. A method as set forth in claim 1 , wherein said step of processing comprises deriving two-dimensional projection image information from said first imaging information.

10. A method as set forth in claim 9 wherein said volumetric imaging information comprises composite information aggregated from images of a series of columns, and said deriving comprises:

establishing a number of projection axes associated with said second projection image information;

for each said projection axis, identifying points of intersection of said axis with peripheries of said volumes; and

using said points of intersection to define said derived two-dimensional projection image information.

11. A method as set forth in claim 9 , wherein said step of processing further comprises segmenting said derived two-dimensional image information by using a threshold value to distinguish first portions of said two-dimensional image information having potential diagnostic value from second portions characterized as reflecting noise.

12. A method as set forth in claim 1 , wherein said step of processing comprises enhancing said second imaging information by using a three-dimensional topology of noise characteristics associated with the second projection information to remove noise therefrom.

13. A method as set forth in claim 1 , wherein said step of processing comprises segmenting said second imaging information to image a location within said region of interest.

14. A method as set forth in claim 13 , wherein said step of segmenting comprises obtaining said second imaging information in relation to a number of pixels, establishing spatial compartments correlated to said pixels, and compartmentalizing said second imaging information relative to said spatial compartments.

15. A method as set forth in claim 14 , wherein said spatial compartments comprise first compartments of a first size and second compartments of a second size where said first compartments and said second compartments correspond to a same spatial region, thereby allowing for different imaging resolutions.

16. A method as set forth in claim 2 , generating a composite image showing first processed information corresponding to said first modality and second processed information corresponding to said second modality.

17. A method as set forth in claim 16 , wherein said first processed information and said second processed information are rendered in said composite image so as to allow for visual discrimination therebetween.

18. A method as set forth in claim 1 , wherein said second imaging information is segmented to identify features of interest, and said processing further involves spatially registering said first segmented imaging information and said second segmented imaging information.

19. A method for use in medical imaging comprising the steps of:

compiling volumetric imaging information of the region of interest, wherein said volumetric imaging information comprises composite information aggregated from images of a series of volumes; and

deriving two-dimensional projection image information from said volumetric imaging information by establishing a number of projection axes for said projection image information;

for each said projection axis, identifying points of intersection of said axis with peripheries of said volumes; and

using said points of intersection to define said derived projection image information.

20. An apparatus for use in medical imaging, comprising:

a first imaging system for acquiring first volumetric imaging information of a region of interest, said first imaging information providing data that is correlated to three spatial dimensions of a reference frame including said region of interest;

a second projection imaging system for acquiring second projection imaging information of said region of interest, said second imaging information providing data that is correlated to said reference frame but is lacking information concerning at least one of said spatial dimensions; and

a processor for processing said first imaging information and said second imaging information such that said first imaging information is registered with said second imaging information with respect to said three spatial dimensions of said reference frame.

Assignments (10)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 035820 FRAME: 0239. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY INTEREST RELEASE. Recorded Nov 9, 2017
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 044727/0529 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 028810 FRAME: 0745. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Nov 9, 2017
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 044432/0565 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 028810/0745 Recorded Jun 4, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 035820/0239 →
SECURITY AGREEMENT Recorded Aug 1, 2012
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 028810/0745 →
TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS Recorded Aug 26, 2010
From: GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT
To: HOLOGIC, INC.; R2 TECHNOLOGY, INC.; SUROS SURGICAL SYSTEMS, INC.; BIOLUCENT, LLC; DIRECT RADIOGRAPHY CORP.; CYTYC SURGICAL PRODUCTS II LIMITED PARTNERSHIP; CYTYC SURGICAL PRODUCTS LIMITED PARTNERSHIP; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS III, INC.; CYTYC PRENATAL PRODUCTS CORP.; THIRD WAVE TECHNOLOGIES, INC.
Reel/Frame 024892/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2010
From: SURI, JASJIT S.; JANER, ROMAN; GUO, YUJUN; ELBAKRI, IDRIS A.
To: HOLOGIC, INC.
Reel/Frame 024841/0037 →
NINTH SUPPLEMENT TO PATENT SECURITY AGREEMENT Recorded Apr 21, 2009
From: HOLOGIC, INC.
To: GOLDMAN SACHS CREDIT PARTNERS L.P., AS COLLATERAL AGENT
Reel/Frame 022571/0410 →