Bone implant composite
View Patent ↗A bone implant composite comprising a collagen matrix and a calcium-based mineral, the calcium-based mineral having a particle size of 25-2000 μm and being interspersed in the collagen matrix; wherein the bone implant composite contains 3-60% by weight the collagen matrix and 40-97% by weight the calcium-based mineral, and has a pore size of 50-500 μm, a density range of 0.02-0.8 g/cm 3 , and a tensile strength range of 0.4-100 kg/cm 2 . Also disclosed are methods of preparing the above-described composite.
1. A bone implant composite comprising a collagen matrix and calcium-based mineral, the calcium-based mineral having a particle size of 25-2000 μm and being interspersed in the collagen matrix; wherein the bone implant composite contains 3-60% by weight the collagen matrix and 40-97% by weight the calcium-based mineral, and has a pore size of 50-500 μm, a density range of 0.02-0.8 g/cm 3 , and a tensile strength range of 0.4-100 kg/cm 2 ; and the bone implant composite is prepared by dispersing collagen fibers and calcium-based mineral in an acidic or basic aqueous solution to form a suspension, freeze-drying the suspension to form a dry mixture, and contacting the dried mixture with a crosslinking agent to crosslink the collagen fibers.
2. The bone implant composite of claim 1 , wherein the particle size of the calcium-based mineral is 30-1000 μm.
3. The bone implant composite of claim 1 , wherein the bone implant composite contains 5-50% by weight the collagen matrix and 50-95% by weight the calcium-based mineral.
4. The bone implant composite of claim 3 , wherein the bone implant composite contains 20-40% by weight the collagen matrix and 60-80% by weight the calcium-based mineral.
5. The bone implant composite of claim 1 , wherein the bone implant composite has a pore size of 150-500 μm.
6. The bone implant composite of claim 1 , wherein the bone implant composite has a density range of 0.03-0.7 g/cm 3 .
7. The bone implant composite of claim 1 , wherein the bone implant composite has a tensile strength range of 0.5-10 kg/cm 2 .
8. The bone implant composite of claim 1 , wherein the calcium-based mineral is anorganic bone mineral.
9. The bone implant composite of claim 1 , wherein the calcium-based mineral is carbonate apatite.
10. The bone implant composite of claim 9 , wherein the carbonate content of the carbonate apatite ranges from 2 to 12%.
11. The bone implant composite of claim 1 , wherein the calcium-based mineral is anorganic bone mineral and has a particle size of 30-1000 μm; and the bone implant composite contains 5-50% by weight the collagen matrix and 50-95% by weight the anorganic bone mineral, and has a pore size of 150-500 μm, a density range of 0.03-0.7 g/cm 3 , and a tensile strength range of 0.5-10 kg/cm 2 .
12. The bone implant composite of claim 11 , wherein the bone implant composite contains 20-40% by weight the collagen matrix and 60-80% by weight the calcium-based mineral.
13. The bone implant composite of claim 1 , wherein the calcium-based mineral is anorganic bone mineral and has a particle size of 30-150 μm; and the bone implant composite contains 45% by weight the collagen matrix and 55% by weight the anorganic bone mineral, and has a pore size of 150-500 μm, a density of 0.04 g/cm 3 , and a tensile strength range of 0.67 kg/cm 2 .
14. The bone implant composite of claim 1 , wherein the calcium-based mineral is carbonate apatite and has a particle size of 30-1000 μm; and the bone implant composite contains 5-50% by weight the collagen matrix and 50-95% by weight the carbonate apatite, and has a pore size of 50-200 μm, a density range of 0.03-0.7 g/cm 3 , and a tensile strength range of 0.5-10 kg/cm 2 .
15. The bone implant composite of claim 14 , wherein the bone implant composite contains 20-40% by weight the collagen matrix and 60-80% by weight the calcium-based mineral.