Oral pharmaceutical formulations containing non-steroidal anti-inflammatory drugs and acid inhibitors
The present disclosure provides enteric coated capsules and orally dissolving films comprising non-steroidal anti-inflammatory drugs and acid inhibitors, as well as methods of treating treatment humans for pain and/or inflammation while reducing gastrointestinal side effects.
1 . An enteric coated capsule comprising a non-steroidal anti-inflammatory drug and an acid inhibitor.
2 . The enteric coated capsule of claim 1 , wherein said enteric coating is selected from methacrylic acid copolymers, hydroxopropyl methylcellulose phthalate, cellulose acetate phthalate and combinations thereof.
3 . The enteric coated capsule of claim 1 , wherein the amount of non-steroidal anti-inflammatory drug is between 1 mg and 500 mg.
4 . The enteric coated capsule of claim 1 , wherein the non-steroidal anti-inflammatory drug is meloxicam.
5 . The enteric coated capsule of claim 4 , wherein the meloxicam is at an amount between 1 mg and 50 mg.
6 . The enteric coated capsule of claim 1 , wherein the acid inhibitor is a proton pump inhibitor.
7 . The enteric coated capsule of claim 6 , wherein the amount of proton pump inhibitor is between 1 mg and 500 mg.
8 . The enteric coated capsule of claim 7 , wherein the acid inhibitor is omeprazole.
9 . The enteric coated capsule of claim 8 , wherein the wherein the omeprazole is at an amount between 1 mg and 100 mg.
10 . A pharmaceutical composition comprising a non-steroidal anti-inflammatory drug and a reversible proton pump inhibitor.
11 . The pharmaceutical composition of claim 10 in which said inhibitors is not enteric coated.
12 . An orally dissolvable film comprising a combination of pharmaceutically active agents, wherein said agents are a non-steroidal anti-inflammatory drug and an acid inhibitor.
13 . The film of claim 12 , wherein the amount of non-steroidal anti-inflammatory drug is between 1 mg and 100 mg.
14 . The film of claim 12 , wherein the non-steroidal anti-inflammatory drug is meloxicam.
15 . The film of claim 12 , wherein the acid inhibitor is enteric coated.
16 . The film of claim 12 , wherein the acid inhibitor is not enteric coated.
17 . The film of claim 12 , wherein the acid inhibitor is a proton pump inhibitor.
18 . The film of claim 17 , wherein the amount of proton pump inhibitor is at an amount between 1 mg and 100 mg.
19 . The film of claim 17 , wherein the wherein the proton pump inhibitor is omeprazole.
20 . The film of claim 19 , wherein omeprazole is enteric coated.
21 . The film of claim 20 , wherein the wherein the omeprazole is at an amount between 1 mg and 100 mg.
22 . The film of claim 12 , wherein the acid inhibitor is an H 2 antagonist.
23 . The film of claim 22 , wherein the H 2 antagonist is at an amount between 5 mg and 50 mg.
24 . The film of claim 22 wherein the H 2 antagonist is famotidine.
25 . An orally dissolvable film comprising meloxicam and enteric coated omeprazole.
26 . A method of treating pain and/or inflammation in a patient comprising administering to said patient a composition according to claim 1 .
27 . A method of protecting the gastrointestinal tract from side effects associated with non-steroidal anti-inflammatory drug therapy in a patient comprising administering to said patient a composition according to claim 1 .
28 . A method of treating pain and/or inflammation in a patient comprising administering to said patient a composition according to claim 12 .
29 . A method of protecting the gastrointestinal tract from side effects associated with non-steroidal anti-inflammatory drug therapy in a patient comprising administering to said patient a composition according to claim 12.