Compounds with medicinal effects due to interaction with the glucocorticoid receptor

1. A compound having the structure according to the formula I

wherein:

X is a nitrogen atom;

Ar is 1H-pyrazole;

R 1 is hydrogen, halogen, CN or (1C-4C)alkyl;

R 2 is hydrogen, halogen or optionally fluorinated (1C-3C)alkoxy;

R 3 and R 5 are independently hydrogen, optionally halogenated (1C-4C)alkyl, optionally halogenated (1C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy, optionally halogenated (1C-4C)alkenyl or hydroxylmethyl;

R 4 is hydrogen, halogen, optionally halogenated (1C-4C)alkoxy or optionally halogenated aryl(1C-4C)alkoxy;

R 6 is optionally halogenated (1C-4C)alkyl; and

each R 7 independently is hydrogen, halogen, optionally halogenated (1C-4C)alkyl or optionally halogenated (1C-4C)alkoxy;

or a pharmaceutically suitable acid addition salt thereof.

2. The compound according to claim 1 , whereby:

R 2 is halogen or optionally fluorinated (1C-3C)alkoxy;

at least one of R 3 , R 4 or R 5 is hydrogen;

R 6 is methyl;

or a pharmaceutically suitable addition salt thereof.

3. The compound according to claim 1 , whereby

R 1 is hydrogen, halogen, CN or methyl;

R 2 is hydrogen, halogen or optionally fluorinated (1C-2C)alkoxy;

R 3 and R 5 are independently hydrogen, (1C-3C)alkyl, benzyloxy, (2C-3C)alkenyl, hydroxylmethyl or optionally fluorinated methoxy;

R 4 is hydrogen, F, Cl or methoxy and at least one of R 3 , R 4 and R 5 is hydrogen;

R 6 is methyl;

each R 7 independently is hydrogen, optionally fluorinated methyl, optionally fluorinated methoxy, F, Cl or Br;

or a pharmaceutically suitable addition salt thereof.

4. The compound according to claim 1 , wherein the compound is N-[(1R)-1-(5-chloro-2-methoxy-3-pyridinyl)phenyl]ethyl-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonamide or a pharmaceutically suitable addition salt thereof.

5. A pharmaceutical composition comprising the compound according to claim 1 or a pharmaceutically suitable addition salt thereof and a pharmaceutically acceptable excipient.

6. A pharmaceutical composition comprising the compound according to claim 4 or a pharmaceutically suitable addition salt thereof and a pharmaceutically acceptable excipient.