IP Library › Granted Patent US 8,828,703
Granted Patent B2
US 8,828,703 · App. 11/646,148 · Granted Sep 9, 2014

Protease inhibition

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,828,703
App. No.
11/646,148
Granted
Sep 9, 2014
Kind
B2
Abstract

Proteins including engineered sequences which inhibit proteases are disclosed, including proteins having two or more engineered Kunitz domains, and uses of such proteins.

Claims (7)

1. An isolated protein comprising two to six engineered Kunitz domain sequences, wherein the protein comprises the amino acid sequence of SEQ ID NO:11, 54, 70, 71, 72, 73, 74, 102, 106, 107 or 127.

2. The isolated protein of claim 1 , wherein the protein does not include a serum albumin moiety.

3. The protein of claim 1 , wherein the protein comprises three Kunitz domains.

4. The protein of claim 1 , wherein the protein comprises four Kunitz domains.

5. The protein of claim 1 , wherein the protein comprises five Kunitz domains.

6. The protein of claim 1 , wherein the protein comprises six Kunitz domains.

7. The protein of claim 1 , wherein the protein is modified with two or more PEG moieties.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 18, 2021
From: DYAX CORP.
To: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Reel/Frame 056268/0983 →