Photogenerated reagents

1. A method of deprotecting protected moieties attached to a solid surface and wherein the moieties have one or more protecting groups comprising: a) contacting the protected moiety with a solution comprising one or more 2-nitroaryl derivatives, the solution comprising one or more 2-nitroaryl derivative(s) having the formula:

wherein

R 1-4 independently of one another are hydrogen (H), Cl, Br, NO 2 , CF 3 , CN, NH 2 , OH, SH, OMe, SMe, acetyl, X 1 —Y—X 2 (X 1 and X 2 independently of one another are N, NH, O, S, carbonyl, thiocarbonyl, C, CH, CH 2 , CH 3 , NH 2 , NH, OH, SH, alkyl, or alkenyl, or alkynyl, or acyl, or aryl, or acylaryl, or heteroaryl, or alkoxyl having 1-18 carbons; Y═NH, O, S, NCH, NHCH, NHCH 2 , CH, CHCH, CH 2 , CH 2 CH 2 , unsubstituted or substituted at one or more positions by Cl, Br, NO 2 , CF 3 , CN, NH 2 , OH, SH, OMe, SMe, (1,2)-benzinyl, benzyl, or alkyl, or alkenyl, or alkynyl, or, acyl, or arylacyl, or aryl, or alkylaryl, or heteroaryl, or alkoxyalkyl, or alkoxyaryl, or phosphonyl alkyl, or phosphonyl aryl, having 1-18 carbons), phenyl, benzyl, or aryl are unstibstitute or substituted at one or more positions by Cl, Br, NO 2 , CF 3 , CN, NH 2 , OH, SH, OMe, or alkyl, or alkenyl, or alkynyl, or, acyl, or arylacyl, or aryl, or alkylaryl, or heteroaryl, or alkoxyalkyl, or alkoxyaryl, or phosphonyl alkyl, or phosphonyl aryl, having 1-18 carbons.

Ra═H, CH 3 , Cl, Br, CN, phenyl, acetyl, or acyl, or heteroaryl, or aryl, or alkyl, or alkenyl, or alkynyl, or alkylaryl, or akoxyalkyl having 1-30 carbons;

X=a Lewis base

(b) irradiating the mixture containing the 2-nitroaryl derivative(s) to produce one or more Lewis base(s) wherein the Lewis bases(s) removes the protecting group(s) from the protected moiety.

2. The method of claim 1 wherein X=

3. The method of claim 1 wherein X=

4. The method of claim 1 wherein the protected moiety contains one or more protected amino group(s).

5. The method of claim 4 wherein the protecting group of the protected amino group is 9-fluorenylmethyloxycarbonyl.

6. The method of claim 4 wherein the protecting group of the protected amino group is base labile.

7. The method of claim 5 wherein 9-fluorenylmethyloxycarbonyl is removed to produce one or more free amino group(s).

8. The method of claim 6 wherein base labile protecting group is removed to produce one or more fire amino group(s).

9. The method of claim 1 wherein the reaction mixture further comprises one or more co-reagent(s).

10. The method of claim 9 wherein the co-reagent is selected from the group consisting of one or more sensitizer(s), acid(s) and base(s).

11. The method of claim 4 wherein the protected moieties bound to a solid support are at least 10 different molecules at different sites.

12. A method for synthesizing a polyamide of desired length and sequence comprising:

(a) forming a surface comprising one or more protected amino acids on a solid support;

(b) forming a reaction mixture comprising the protected amino acids and one or more 2-nitroaryl derivative(s) having the formula:

wherein

R 1-4 independently of one another are hydrogen (H), Cl, Br, NO 2 , CF 3 , CN, NH 2 , OH, SH, OMe, SMe, acetyl, X 1 —Y—X 2 (X 1 and X 2 independently of one another are N, NH, O, S, carbonyl, thiocarbonyl, C, CH, CH 2 , CH 3 , NH 2 , NH, OH, SH, alkyl, or alkenyl, or alkynyl, or acyl, or aryl, or acylaryl, or heteroaryl, or alkoxyl having 1-18 carbons; Y═NH, O, S, NCH, NHCH, NHCH 2 , CH, CHCH, CH 2 , CH 2 CH 2 , unsubstituted or substituted at one or more positions by Cl, Br, NO 2 , CF 3 , CN, NH 2 , OH, SH, OMe, SMe, (1,2)-benzinyl, benzyl, or alkyl, or alkenyl, or alkynyl, or, acyl, or arylacyl, or aryl, or alkylaryl, or heteroaryl, or alkoxyalkyl, or alkoxyaryl, or phosphonyl alkyl, or phosphonyl aryl, having 1-18 carbons), phenyl, benzyl, or aryl are unsubstitute or substituted at one or more positions by Cl, Br, NO 2 , CF 3 , CN, NH 2 , OH, SH, OMe, or alkyl, or alkenyl, or alkynyl, or, acyl, or arylacyl, or aryl, or alkylaryl, or heteroaryl, or alkoxyalkyl, or alkoxyaryl, or phosphonyl alkyl, or phosphonyl aryl, having 1-18 carbons; Ra═II, CH 3 , Cl, Br, CN, phenyl, acetyl, or acyl, or heteroaryl, or aryl, or alkyl, or alkenyl, or alkynyl, or alkylaryl, or akoxyalkyl having 1-30 carbons; and, X=a Lewis base;

(c) adding the mixture to the said surface;

(d) irradiating the mixture containing the 2-nitroaryl derivative(s) to produce one or more Lewis base(s), wherein the Lewis base(s) removes the protecting group from the protected amino acid to form a deprotected amino acid;

(e) coupling a protected amino acid to the deprotected amino acid; and

(f) repeating steps (c) through (e) until a polyamide chain of the desired length is formed.

13. A method for synthesizing a polyamide of desired length comprising:

(a) forming a surface on a solid support;

(b) forming a reaction mixture comprising one or more 2-nitroaryl derivative(s) having the formula

wherein

R 1-4 independently of one another are hydrogen (H), Cl, Br, NO 2 , CF 3 , CN, NH 2 , OH, SH, OMe, SMe, acetyl, X 1 —Y—X 2 (X 1 and X 2 independently of one another are N, NH, O, S, carbonyl, thiocarbonyl, C, CH, CH 2 , CH 3 , NH 2 , NH, OH, SH, alkyl, or alkenyl, or alkynyl, or acyl, or aryl, or acylaryl, or heteroaryl, or alkoxyl having 1-18 carbons; Y═NH, O, S, NCH, NHCH, NHCH 2 , CH, CHCH, CH 2 , CH 2 CH 2 , unsubstituted or substituted at one or more positions by Cl, Br, NO 2 , CF 3 , CN, NH 2 , OH, SH, OMe, SMe, (1,2)-benzinyl, benzyl, or alkyl, or alkenyl, or alkynyl, or, acyl, or arylacyl, or aryl, or alkylaryl, or heteroaryl, or alkoxyalkyl, or alkoxyaryl, or phosphonyl alkyl, or phosphonyl aryl, having 1-18 carbons), phenyl, benzyl, or aryl are unsubstitute or substituted at one or more positions by Cl, Br, NO 2 , CF 3 , CN, NH 2 , OH, SH, OMe, or alkyl, or alkenyl, or alkynyl, or, acyl, or arylacyl, or aryl, or alkylaryl, or heteroaryl, or alkoxyalkyl, or alkoxyaryl, or phosphonyl alkyl, or phosphonyl aryl, having 1-18 carbons; Ra═H, CH 3 , Cl, Br, CN, phenyl, acetyl, or acyl, or heteroaryl, or aryl, or alkyl, or alkenyl, or alkynyl, or alkylaryl, or akoxyalkyl having 1-30 carbons; and, X=a Lewis base;

(c) adding the mixture to the said surface;

(d) irradiating the mixture containing the 2-nitroaryl derivative(s) to produce one or more Lewis base(s);

(e) adding the irradiated mixture to a different site comprising protected amino acids, wherein the Lewis base(s) removes the protecting group from protected amino acids;

(f) coupling the added protected amino acid to the deprotected amino acid; and,

(g) repeating steps (c) through (f) until a polyamide chain of the desired length is formed.

14. A method for synthesizing a polyamide of desired length comprising:

(a) forming a surface comprising protected moieties a solid support;

(b) forming a reaction mixture comprising the protected moieties and one or more 2-nitroaryl derivative(s) having the formula:

wherein

R 1-4 independently of one another are hydrogen (H), Cl, Br, NO 2 , CF 3 , CN, NH 2 , OH, SH, OMe, SMe, acetyl, X 1 —Y—X 2 (X 1 and X 2 independently of one another are N, NH, O, S, carbonyl, thiocarbonyl, C, CH, CH 2 , CH 3 , NH 2 , NH, OH, SH, alkyl, or alkenyl, or alkynyl, or acyl, or aryl, or acylaryl, or heteroaryl, or alkoxyl having 1-18 carbons; Y═NH, O, S, NCH, NHCH, NHCH 2 , CH, CHCH, CH 2 , CH 2 CH 2 , unsubstituted or substituted at one or more positions by Cl, Br, NO 2 , CF 3 , CN, NH 2 , OH, SH, OMe, SMe, (1,2)-benzinyl, benzyl, or alkyl, or alkenyl, or alkynyl, or, acyl, or arylacyl, or aryl, or alkylaryl, or heteroaryl, or alkoxyalkyl, or alkoxyaryl, or phosphonyl alkyl, or phosphonyl aryl, having 1-18 carbons), phenyl, benzyl, or aryl are unsubstitute or substituted at one or more positions by Cl, Br, NO 2 , CF 3 , CN, NH 2 , OH, SH, OMe, or alkyl, or alkenyl, or alkynyl, or, acyl, or arylacyl, or aryl, or alkylaryl, or heteroaryl, or alkoxyalkyl, or alkoxyaryl, or phosphonyl alkyl, or phosphonyl aryl, having 1-18 carbons; Ra═H, CH 3 , Cl, Br, CN, phenyl, acetyl, or acyl, or heteroaryl, or aryl, or alkyl, or alkenyl, or alkynyl, or alkylaryl, or akoxyalkyl having 1-30 carbons; and, X=a Lewis base;

(c) adding the mixture to the said surface;

(d) irradiating the mixture containing the 2-nitroaryl derivative(s) to produce one or more Lewis base(s), wherein the Lewis bases(s) removes the protecting group from the protected moiety to form a deprotected moiety;

(e) coupling added protected building block to the deprotected moiety; and,

(f) repeating steps (c) through (e) until a polyamide chain of the desired length is formed.