GI inflammatory disease treatment
View Patent ↗Methods and an apparatus are described for treating at least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient. Embodiments include a method for treating a patient having a gastro-intestinal disorder having a inflammatory basis, including positioning an electrode on a vagus nerve below a vagal innervation of a heart of the patient, and treating the patient's gastro-intestinal disorder by applying an electrical signal to the electrode, wherein the signal has a frequency of at least 500 Hz and is selected to down-regulate neural activity on the vagus nerve, allow partial restoration of nerve activity upon discontinuation of the electrical signal, and wherein the signal is configured to reduce pancreatic output and biliary output. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be blocking or a stimulation signal.
1. A method for treating a patient having a gastro-intestinal disorder having an inflammatory basis, comprising:
positioning an electrode on a vagus nerve below a vagal innervation of a heart of the patient, with the nerve innervating at least one of a plurality of alimentary tract organs; and
treating the patient's gastro-intestinal disorder by applying an electrical signal to the electrode, wherein the signal has a frequency of at least 500 Hz and is selected to down-regulate neural activity on the vagus nerve, allow partial restoration of nerve activity upon discontinuation of the electrical signal, and wherein the signal is configured to reduce pancreatic and biliary output via inhibition of pancreo-biliary output.
2. A method according to claim 1 wherein the electrical signal is applied at a frequency selected for the signal to create a neural conduction block on the nerve at a blocking site with the neural conduction block selected to at least partially block nerve impulses on the nerve at the blocking site.
3. A method according to claim 2 wherein application of the neural conduction block is variable by a controller to alter a characteristic of the block.
4. A method according to claim 1 wherein the electrode is placed on the vagus nerve at an esophagus of the patient.
5. A method according to claim 1 wherein the signal has a frequency of about 5,000 Hz.
6. A method according to claim 1 wherein the signal is applied to a trunk of the vagus nerve.
7. A method according to claim 1 wherein the signal is applied to a branch of the vagus nerve.
8. A method according to claim 1 wherein the signal is applied to both an anterior vagus nerve and a posterior vagus nerve of the patient.
9. A method according to claim 1 wherein the signal is applied to the vagus nerve at a location near or distal to a diaphragm of the patient.
10. A method according to claim 1 wherein the signal is selected to at least partially block afferent nerve signals.
11. A method according to claim 1 wherein the signal is selected to at least partially block efferent nerve signals.
12. A method according to claim 1 wherein the signal is selected to at least partially block both afferent and efferent nerve signals.
13. A method according to claim 1 wherein the disorder is Crohn's disease.