Methods and compositions for oral delivery of FTS
View Patent ↗Disclosed are oral dosage forms containing a Ras antagonist including FTS and structural analogs thereof, and at least one pharmaceutically acceptable excipient other than a cyclodextrin, and methods of orally administering same to treat diseases and disorders responsive to the Ras antagonists.
1. A method of treating cancer, comprising administering to a human in need thereof an oral dosage form comprising an amount of a Ras antagonist effective to treat the cancer, and a pharmaceutically acceptable carrier other than a cyclodextrin, wherein said Ras antagonist is S-farnesyl-thiosalicylic acid as represented by the formula
wherein:
R 1 represents farnesyl;
R 2 is COOR 7 , wherein R 7 is hydrogen;
R 3 , R 4 , R 5 and R 6 are each independently hydrogen; and
X represents S, wherein the oral dosage form is a tablet or capsule.
2. The method of claim 1 , wherein the cancer is breast cancer.
3. The method of claim 1 , wherein the cancer is pancreatic cancer.
4. The method of claim 1 , wherein the cancer is colon cancer.
5. The method of claim 1 , wherein the cancer is lung cancer.
6. The method of claim 5 , wherein the lung cancer is non-small cell lung cancer.
7. The method of claim 1 , wherein the cancer is ovarian cancer.
8. The method of claim 1 , wherein the cancer is prostate cancer.
9. The method of claim 1 , wherein the cancer is a gioblastoma.
10. The method of claim 1 , wherein the cancer is a melanoma.