IP Library Granted Patent US 7,850,858
Granted Patent B2
US 7,850,858 · App. 11/661,320 · Granted Dec 14, 2010

Granulocyte adsorbent

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,850,858
App. No.
11/661,320
Granted
Dec 14, 2010
Kind
B2
Abstract

This invention relates to a granulocyte adsorbent comprising a polymer compound having an unsubstituted hydroxyl group and a hydroxyl group in which H has been substituted with at least one substituent R, a method for producing such adsorbent, a device for adsorbing granulocytes and a system for removing granulocytes using such adsorbent, and body fluid or a cell suspension from which granulocytes have been removed using such adsorbent.

Claims (15)

1. A granulocyte adsorbent comprising a polymer compound having an unsubstituted hydroxyl group and a hydroxyl group in which H has been substituted with acetyl, wherein the polymer compound is at least one selected from

cellulose acetate in which the percentage of hydroxyl groups substituted with acetyl groups is 44% to 51% among all hydroxyl groups, and

polyvinyl acetate in which the percentage of hydroxyl groups substituted with acetyl groups is 35% to 49% among all hydroxyl groups.

2. The granulocyte adsorbent according to claim 1 , which is insoluble in water.

3. A device comprising a container that contains the granulocyte adsorbent according to claim 1 .

4. The device according to claim 3 , wherein the container comprises an inlet and an outlet for liquid.

5. The granulocyte adsorbent according to claim 1 used for extracorporeal circulation.

6. A system for removing granulocytes used for extracorporeal circulation comprising a device comprising a container containing the granulocyte adsorbent according to claim 5 , a pump for transporting body fluid, and a pump for injecting an anticoagulant.

7. A method for producing a granulocyte adsorbent comprising steps of:

(a) obtaining polyvinyl acetate; and

(b) cleaving part of acetyl groups of said polyvinyl acetate by treating said polyvinyl acetate under alkaline conditions,

wherein said polyvinyl acetate has an unsubstituted hydroxyl group and a hydroxyl group in which H has been substituted with acetyl, wherein the percentage of hydroxyl groups substituted with acetyl groups in said polyvinyl acetate is 35% to 49% among all hydroxyl groups.

8. A method for preparing body fluid or a cell suspension from which granulocytes have been removed comprising steps of:

(a) bringing body fluid obtained from a mammalian animal or a cell suspension derived therefrom into contact with the granulocyte adsorbent according to claim 1 ; and

(b) obtaining body fluid or a cell suspension from which granulocytes have been removed.

Assignments (2)
CHANGE OF ADDRESS Recorded Jan 15, 2014
From: KANEKA CORPORATION
To: KANEKA CORPORATION
Reel/Frame 032019/0901 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2007
From: KOBAYASHI, AKIRA; YOSHIDA, SHINYA; NIWA, HIDEO
To: KANEKA CORPORATION
Reel/Frame 019001/0259 →