Substituted phenylaminothiazoles and use thereof
View Patent ↗The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
1. A compound of formula (I)
in which
R 1 represents hydrogen or represents (C 1 -C 6 )-alkyl which may be substituted by hydroxyl, amino, or mono- or di-(C 1 -C 4 )-alkylamino,
R 2 represents (C 2 -C 6 )-alkyl which is mono- or disubstituted by identical or different substituents selected from the group consisting of hydroxyl, (C 1 -C 4 )-alkoxy, amino, mono- and di-(C 1 -C 4 )-alkylamino,
R 3 represents a substituent selected from the group consisting of halogen, cyano, nitro, (C 1 -C 6 )-alkyl, hydroxyl, (C 1 -C 6 )-alkoxy, amino, mono- and di-( C 1 -C 6 )-alkylamino, carboxyl and (C 1 -C 6 )-alkoxycarbonyl,
where alkyl and alkoxy for their part may in each case be substituted up to five times by fluorine, and
n represents the number 0, 1, 2, 3, 4 or 5,
where, if the substituent R 3 is present more than once, its meanings may be identical or different,
or a salt, thereof.
2. The compound of formula (I) according to claim 1 , in which
R 1 represents hydrogen or represents (C 1 -C 4 )-alkyl which may be substituted by hydroxyl, amino or dimethylamino,
R 2 represents (C 2 -C 4 )-alkyl which is mono- or disubstituted by identical or different substituents selected from the group consisting of hydroxyl, methoxy and amino,
R 3 represents a substituent selected from the group consisting of halogen, cyano, nitro, (C 1 -C 4 )-alkyl, hydroxyl, (C 1 -C 4 )-alkoxy, amino, mono- and di-(C 1 -C 4 )-alkylamino, carboxyl and (C 1 -C 4 )-alkoxycarbonyl,
where alkyl and alkoxyl for their part may in each case be substituted up to three times by fluorine, and
n represents the number 0, 1 or 2,
where, if the substituent R 3 is present twice, its meanings may be identical or different.
3. The compound of formula (I) according to claim 1 ,
in which
R 1 represents hydrogen,
R 2 represents ethyl, n-propyl or isopropyl which are in each case mono- or disubstituted by identical or different substituents selected from the group consisting of hydroxyl, methoxy and amino,
R 3 represents a substituent selected from the group consisting of fluorine, chlorine, bromine, cyano, nitro, methyl, ethyl, trifluoromethyl, hydroxyl, methoxy, ethoxy, amino, mono- and dimethylamino, carboxyl, methoxycarbonyl and ethoxycarbonyl, and
n represents the number 0, 1 or 2,
where, if the substituent R 3 is present twice, its meanings may be identical or different.
4. A pharmaceutical composition comprising a compound according to claim 1 and an inert, nontoxic, pharmaceutically suitable auxiliary.