Controlled delivery system
View Patent ↗The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided. Preferably the composition contains bupivacaine and a sugar ester such as saib.
1. A composition comprising:
20% to 10% by weight bupivacaine free base relative to the total weight of the composition;
about 75% to about 25% by weight sucrose acetate isobutyrate (SAIB) relative to the total weight of the composition; and about 55% to about 10% by weight benzyl alcohol relative to the total weight of the composition; wherein upon administration to a subject, bupivacaine is released from the composition in an amount sufficient to provide a local anesthetic effect at a site of administration for at least 24 hours after administration.
2. A method for providing sustained local anesthesia to a subject, said method comprising administering to the subject the composition of claim 1 .
3. The method of claim 2 , wherein said administering is by topical application.
4. The method of claim 2 , wherein said administering is by injection.
5. The method of claim 2 , wherein said administering comprises administering as an implant.
6. The method of claim 2 , wherein the site is a surgical wound.
7. The method of claim 2 , wherein the composition is administered in or adjacent a surgical wound.
8. The composition of claim 1 , wherein said composition is suitable for topical, systemic, or parenteral administration.
9. The composition of claim 1 , wherein said composition is suitable for administration via injection, pouring, spraying, dipping, aerosolizing, or via a coating applicator.
10. The method of claim 2 , wherein said composition is administered by pouring.
11. The method of claim 2 , wherein said subject is a human patient undergoing surgical inguinal hernia repair or an appendectomy.
12. The method of claim 2 , wherein said composition is used to treat post-operative pain.
13. The method of claim 2 , wherein less than about 20% of the bupivacaine present in the composition is released within 24 hours after administration.
14. The composition of claim 1 , wherein the SAIB and the benzyl alcohol form a low viscosity liquid carrier material having a viscosity ranging from 200 cP to 6000 cP.
15. The composition of claim 1 , wherein the composition does not comprise a polymer.
16. The method of claim 2 , wherein the administering does not comprise injection.
17. The composition of claim 1 , wherein the composition provides the local anesthetic effect up to 4 days after administration.
18. A composition comprising:
20% to 10% by weight bupivacaine free base relative to the total weight of the composition;
sucrose acetate isobutyrate (SAIB) present in an amount of from about 75% to about 25% by weight relative to the total weight of the composition; and
benzyl alcohol present in an amount of from about 50% to about 15% by weight relative to the total weight of the composition,
wherein upon administration to a subject, bupivacaine is released from the composition in an amount sufficient to provide a local anesthetic effect at a site of administration for at least 24 hours after administration.
19. The composition of claim 18 , wherein the composition provides the local anesthetic effect for at least 36 hours after administration.
20. The composition of claim 19 , wherein the composition provides the local anesthetic effect for at least 48 hours after administration.
21. The composition of claim 18 , wherein said composition is suitable for topical, systemic, or parenteral administration.
22. The composition of claim 18 , wherein said composition is suitable for administration via injection, pouring, spraying, dipping, aerosolizing, or via a coating applicator.
23. The composition of claim 18 , wherein the SAIB and the benzyl alcohol form a low viscosity liquid carrier material having a viscosity ranging from 200 cP to 6000 cP.
24. The composition of claim 18 , wherein the composition does not comprise a polymer.
25. The composition of claim 18 , wherein the composition provides the local anesthetic effect up to 4 days after administration.
26. A method for providing sustained local anesthesia to a subject, said method comprising administering to the subject the composition of claim 18 .
27. The method of claim 26 , wherein said administering is by topical application.
28. The method of claim 26 , wherein said administering is by injection.
29. The method of claim 26 , wherein said administering comprises administering as an implant.
30. The method of claim 26 , comprising administering to a surgical wound.
31. The method of claim 26 , wherein the composition is administered in or adjacent a surgical wound.
32. The method of claim 26 , wherein said composition is administered by pouring.
33. The method of claim 26 , wherein said subject is a human patient undergoing surgical inguinal hernia repair or an appendectomy.
34. The method of claim 26 , wherein said composition is used to treat post-operative pain.
35. The method of claim 26 , wherein less than about 20% of the bupivacaine present in the composition is released within 24 hours after administration.
36. The method of claim 26 , wherein the administering does not comprise injection.