Hydrogel composition
View Patent ↗An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.
1. A hydrogel composition comprising a first monomer, a second monomer, a cross-linking agent, and a solvent, the first monomer being selected from Formula I:
wherein the combination of R and R1 is selected from 1 carbon to 5 carbon atoms such that a 3-7 member heterocyclic moiety is formed;
the second monomer being selected from Formula III
wherein R5 is (C3-C7)cycloalkyl, wherein the cycloalkyl is optionally substituted with one or more substituents selected from alkyls, halos, haloalkyls, cycloalkyls, nitros, and cyanos; and wherein the ratio of the first monomer to the second monomer is from about 20:80 to about 80:20.
2. The hydrogel composition of claim 1 , wherein the cross-linking agent is a multifunctional vinyl ether, a divinylbenzene, a multifunctional acrylate, or a multifunctional acrylamide.
3. The hydrogel composition of claim 2 , wherein the cross-linking agent is a multifunctional vinyl ether, the multifunctional vinyl ether being a diethylene glycol divinyl ether acrylate, triethylene glycol divinyl ether, and tetra(ethylene glycol) divinyl ether.
4. The hydrogel composition of claim 2 , wherein the cross-linking agent is a divinylbenzene.
5. The hydrogel composition of claim 2 , wherein the cross-linking agent is a multifunctional acrylate, the multifunctional acrylate being ethylene glycol dimethacrylate (EGDMA), polyethylene glycol diacrylates, diethylene glycol dimethacrylate, diethylene glycol diacrylate, ethylene glycol diacrylate, or 1,3-dihydroxypropyldimethacrylate.
6. The hydrogel composition of claim 2 , wherein the cross-linking agent is a multifunctional acrylamide.
7. The hydrogel composition of claim 1 , wherein the solvent is water.
8. The hydrogel composition of claim 1 , further including a photo-initiator.
9. The hydrogel composition of claim 1 , wherein the ratio of the first monomer to the second monomer is from about 40:60 to about 60:40.
10. The hydrogel composition of claim 1 , wherein the first monomer is N-vinyl pyrrolidone or N-vinyl caprolactam, the second monomer being selected from Formula III with R5 being a (C 3 -C 7 )cycloalkyl that is optionally substituted.